Solid Lipid Nanoparticles for Drug Delivery: Pharmacological and Biopharmaceutical Aspects
October 2020
in “
Frontiers in Molecular Biosciences
”
TLDR Solid lipid nanoparticles are promising for safe and effective drug delivery but need more research for clinical use.
The document reviewed the state of solid lipid nanoparticles (SLNs) as drug delivery systems, highlighting their non-toxic, biocompatible, and easy-to-produce nature. It discussed the pharmacokinetic aspects, including administration routes, absorption, distribution, and elimination, as well as safety and toxicity concerns. The review emphasized the need for systematic preformulation studies and explored the therapeutic applications and advantages of SLNs. It also analyzed the current landscape of SLN research through a bibliographic search covering 2013-2020, noting the limited number of SLNs in clinical trials and identifying milestones needed for their clinical translation.
