Nanoparticles for Topical Application in the Treatment of Skin Dysfunctions: An Overview of Dermo-Cosmetic and Dermatological Products

    Magdalena Raszewska-Famielec, Jolanta Flieger
    Studysummary In this review, researchers discussed recent advances in nanotechnology for topical skin applications, highlighting how nanocarriers enhance skin penetration and targeting in treatments for diseases like melanoma and psoriasis, while acknowledging that the penetration mechanisms and health impacts of nanoparticles remain not fully understood.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on mdpi.com →
    Discuss this study in the Community →

    Research cited in this study 32

    1. Nanocarriers as Active Ingredients Enhancers in the Cosmetic Industry—The European and North America Regulation Challenges Molecules · 2022
    2. Nanostructured Lipid Carriers Loaded with Minoxidil and Latanoprost for Targeted Topical Therapy of Alopecia European Journal of Pharmaceutics and Biopharmaceutics · 2022
    3. Latanoprost Loaded in Polymeric Nanocapsules for Effective Topical Treatment of Alopecia AAPS PharmSciTech · 2020
    4. Potential of Nanoparticles as Permeation Enhancers and Targeted Delivery Options for Skin: Advantages and Disadvantages Drug Design Development and Therapy · 2020
    5. Drug Delivery System Based On Minoxidil Nanoparticles Promotes Hair Growth In C57BL/6 Mice International Journal of Nanomedicine · 2019
    6. Cyproterone Acetate-Loaded Nanostructured Lipid Carriers: Effect of Particle Size on Skin Penetration and Follicular Targeting Pharmaceutical development and technology · 2019
    7. Skin Permeability and Transdermal Delivery Route of 50-nm Indomethacin-Loaded PLGA Nanoparticles Colloids and Surfaces B: Biointerfaces · 2017
    8. Fullerene Nanoparticles in Dermatological and Cosmetic Applications Nanomedicine: Nanotechnology, Biology and Medicine · 2016
    9. Do Nanoparticles Have a Future in Dermal Drug Delivery? Journal of Controlled Release · 2016
    10. Eupafolin Nanoparticles Protect HaCaT Keratinocytes from Particulate Matter-Induced Inflammation and Oxidative Stress International Journal of Nanomedicine · 2016
    11. Preparation and Characterization of Minoxidil Loaded Nanostructured Lipid Carriers Aaps Pharmscitech · 2016
    12. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study Advanced Pharmaceutical Bulletin · 2016
    13. The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study PubMed · 2016
    14. Systematically Optimized Coenzyme Q10-Loaded Novel Proniosomal Formulation for Treatment of Photo-Induced Aging in Mice: Characterization, Biocompatibility Studies, Biochemical Estimations, and Anti-Aging Evaluation Journal of Drug Targeting · 2015
    15. Applications and Limitations of Lipid Nanoparticles in Dermal and Transdermal Drug Delivery via the Follicular Route European journal of pharmaceutics and biopharmaceutics · 2015
    16. Chitosan Nanoparticles for Targeting and Sustaining Minoxidil Sulphate Delivery to Hair Follicles International Journal of Biological Macromolecules · 2015
    17. In Vivo Penetration of Bare and Lipid-Coated Silica Nanoparticles Across the Human Stratum Corneum Colloids and surfaces. B, Biointerfaces · 2014
    18. Getting Under the Skin: What Is the Potential of the Transfollicular Route in Drug Delivery? Therapeutic delivery · 2014
    19. Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis Molecular pharmaceutics · 2014
    20. Penetration and Storage of Particles in Human Skin: Perspectives and Safety Aspects European Journal of Pharmaceutics and Biopharmaceutics · 2011
    21. Selective Follicular Targeting by Modification of the Particle Sizes Journal of Controlled Release · 2011
    22. Focus on Skin as a Possible Port of Entry for Solid Nanoparticles and the Toxicological Impact Journal of biomedical nanotechnology · 2010
    23. Determination of the Cuticle Thickness of Human and Porcine Hairs and Their Potential Influence on the Penetration of Nanoparticles into the Hair Follicles Journal of Biomedical Optics · 2009
    24. Nanoparticle-Based Targeting of Vaccine Compounds to Skin Antigen-Presenting Cells by Hair Follicles and Their Transport in Mice ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2008
    25. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008
    26. Evaluation of the Permeability of Hair Growing Ingredient Encapsulated PLGA Nanospheres to Hair Follicles and Their Hair Growing Effects Bioorganic & Medicinal Chemistry Letters · 2007
    27. Development of Liposomal Systems of Finasteride for Topical Applications: Design, Characterization, and In Vitro Evaluation Pharmaceutical Development and Technology · 2007
    28. 40nm, But Not 750 or 1,500nm, Nanoparticles Enter Epidermal CD1a+ Cells After Transcutaneous Application on Human Skin ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2006
    29. Reorganization of Hair Follicles in Human Skin Organ Culture Induced by Cultured Human Follicle-Derived Cells Experimental Dermatology · 2005
    30. Liposomes and Niosomes as Topical Drug Delivery Systems Skin pharmacology and physiology · 2005
    31. Variations of Hair Follicle Size and Distribution in Different Body Sites Journal of Investigative Dermatology · 2004
    32. Efficient Delivery of Transgenes to Human Hair Follicle Progenitor Cells Using Topical Lipoplex Nature biotechnology · 2000