Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis

July 2014 in “ Molecular pharmaceutics ”

Maria Lapteva, Karine Mondon, Michael Möller, Robert Gurny, Yogeshvar N. Kalia

tacrolimus polymeric micelles MPEG-dihexPLA cutaneous delivery Protopic stratum corneum viable epidermis upper dermis hair follicles confocal laser scanning microscopy TAC

Studysummary This study found that MPEG-dihexPLA micelles significantly improved the skin deposition of tacrolimus compared to a marketed ointment, suggesting better targeted delivery with reduced systemic absorption.

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