Novel Micelle Formulations to Increase Cutaneous Bioavailability of Azole Antifungals

March 2011 in “ Journal of controlled release ”

Yogeshwar Bachhav, Karine Mondon, Yogeshvar N. Kalia, Robert Gurny, Michael Möller

azole antifungals clotrimazole econazole nitrate fluconazole micelle formulations cutaneous bioavailability block copolymers MPEG-dihexPLA micelles follicular penetration hair follicles CLZ ECZ FLZ

Studysummary This study found that econazole nitrate delivered via MPEG-dihexPLA micelles significantly increased skin deposition compared to Pevaryl® cream, potentially enhancing drug bioavailability and clinical efficacy.

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