Topical Ketoconazole: A Systematic Review of Current Dermatological Applications and Future Developments

January 2019 in “ Journal of Dermatological Treatment ”

Franchesca Choi, Margit Juhász, Natasha Atanaskova Mesinkovska

From the encyclopedia

antifungal with some anti-androgenic benefits, often used as a shampoo

Frontline, gold standard treatment for combatting androgenic alopecia

Studysummary This review found topical ketoconazole to be highly effective against Malassezia-related skin conditions, though other treatments may outperform it for Tinea and Candida infections.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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This study demonstrated that Ketoconazole, Minoxidil, and Minoxidil with Tretinoin all significantly stimulated hair growth in mice, with Minoxidil alone showing the most effectiveness.

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research Topical Application of Ketoconazole Stimulates Hair Growth in C3H/HeN Mice

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This study found that 2% ketoconazole solution stimulated hair growth significantly in a mouse model, suggesting potential benefits for male pattern hair loss.

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This paper suggests that ketoconazole 2% shampoo may enhance finasteride's effectiveness in treating androgenetic alopecia by more completely inhibiting the dihydrotestosterone pathway.

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research Treatment of Hair Loss

370 citations , September 1999 in “The New England Journal of Medicine”

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research Ketoconazole Shampoo: Effect of Long-Term Use in Androgenic Alopecia

92 citations , January 1998 in “Dermatology”

This study found that 2% ketoconazole shampoo improved hair density and anagen follicle proportion in androgenic alopecia similarly to minoxidil treatment, suggesting a potential role for Malassezia in inflammation.

research Antiandrogen Therapy in Dermatology

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research Improvement in the Inflammatory Aspect of Androgenetic Alopecia: A Pilot Study with an Antimicrobial Lotion

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This study found that using an antimicrobial lotion for 18 months may reduce inflammation and potentially partially reverse hair loss in men with androgenetic alopecia.