Polymeric Micelle Mediated Follicular Delivery of Spironolactone: Targeting the Mineralocorticoid Receptor to Prevent Glucocorticoid-Induced Activation and Delayed Cutaneous Wound Healing

    June 2021 in “ International Journal of Pharmaceutics ”
    Naoual Dahmana, Thibault Mugnier, Doris Gabriel … Yogeshvar N. Kalia
    Studysummary This study found that polymeric micelle nanocarriers delivered pharmacologically relevant amounts of spironolactone to the epidermis and upper dermis, with higher delivery to pilosebaceous units, suggesting potential for treating glucocorticoid-induced impaired wound healing and pilosebaceous androgen-related skin diseases.
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    Research cited in this study 13

    1. Selective Delivery of Adapalene to the Human Hair Follicle Under Finite Dose Conditions Using Polymeric Micelle Nanocarriers Nanoscale · 2017
    2. Self-Assembled Polymeric Nanocarriers for the Targeted Delivery of Retinoic Acid to the Hair Follicle Nanoscale · 2015
    3. Follicular Delivery of Spironolactone via Nanostructured Lipid Carriers for Management of Alopecia International Journal of Nanomedicine · 2014
    4. Getting Under the Skin: What Is the Potential of the Transfollicular Route in Drug Delivery? Therapeutic delivery · 2014
    5. Polymeric Micelle Nanocarriers for the Cutaneous Delivery of Tacrolimus: A Targeted Approach for the Treatment of Psoriasis Molecular pharmaceutics · 2014
    6. Drug Delivery to Hair Follicles Expert opinion on drug delivery · 2013
    7. The Mineralocorticoid Receptor as a Novel Player in Skin Biology: Beyond the Renal Horizon? Experimental Dermatology · 2009
    8. The Skin as an Endocrine Organ Dermato-endocrinology · 2009
    9. Hormones and the Pilosebaceous Unit Dermato-endocrinology · 2009
    10. Sexual Hormones in Human Skin Hormone and metabolic research · 2007
    11. Transfollicular Drug Delivery: Is It a Reality? International journal of pharmaceutics · 2005
    12. Beneficial Effect of Spironolactone on Androgenic Alopecia Clinical Endocrinology · 1997
    13. Oral Spironolactone Therapy for Female Patients with Acne, Hirsutism, or Androgenic Alopecia British Journal of Dermatology · 1985