Selective Delivery of Adapalene to the Human Hair Follicle Under Finite Dose Conditions Using Polymeric Micelle Nanocarriers

The study aimed to enhance the delivery of adapalene (ADA) to the pilosebaceous unit (PSU) using polymeric micelle nanocarriers. Researchers prepared micelles with D-α-tocopheryl polyethylene glycol succinate diblock copolymer, significantly increasing ADA's solubility. Stability tests and finite dose experiments on porcine and human skin showed that micelle formulations delivered ADA more efficiently to the PSU compared to commercial products. Follicular delivery studies confirmed that micelle formulations achieved higher ADA concentrations in the PSU, supported by confocal laser scanning microscopy. The findings suggested that polymeric micelle nanocarriers could improve treatment of follicular diseases and reduce side effects.