Intradermal and Follicular Delivery of Adapalene Liposomes

    Vijay Kumar, Ajay K. Banga
    TLDR Liposomal adapalene improves delivery to hair follicles and reduces side effects for acne treatment.
    The study prepared and evaluated a liposomal formulation of adapalene to improve its delivery to hair follicles and reduce side effects. The liposomes, with a diameter of 86.66 ± 3.5 nm and an encapsulation efficiency of 97.01 ± 1.84% w/w, showed enhanced drug delivery in vitro, delivering 6.72 ± 0.83 μg/cm² to hair follicles compared to 3.33 ± 0.26 μg/cm² from gel and 1.62 ± 0.054 μg/cm² from drug solution. Confocal microscopy confirmed drug penetration in hair follicles, indicating that liposomal encapsulation effectively targeted the desired site for acne treatment.
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