TLDR New liposomal formulations may improve delivery of treatments to hair follicles, potentially helping with hair loss.
The document discusses the development of novel liposomal formulations aimed at improving the topical delivery of active agents directly to hair follicles and sebaceous glands, which could be beneficial for treating skin diseases like hair loss. The research focused on both small and large molecules, using minoxidil, a known hair growth stimulator, as the small molecule example, and plasmid DNA encoded with interleukin-1 receptor antagonist protein (IL-1ra) as the large molecule example. This suggests a shift in the scientific community towards recognizing follicular transport as a viable pathway for the delivery of topical treatments.
2 citations
,
April 2021 in “International Journal of Pharmaceutics” Serum formulations were better at delivering molecules to the hair bulb than nanoparticles.
1 citations
,
January 2001 in “Journal of Toxicology-cutaneous and Ocular Toxicology” Hair follicles could be used to deliver drugs effectively, with the right understanding and methods.
1 citations
,
July 2005 in “Informa Healthcare eBooks” Hair follicles could be used for targeted drug delivery, with liposomal systems showing promise for this method.
10 citations
,
April 2016 in “Research and reports in transdermal drug delivery” Transfollicular drug delivery is promising but needs more research to improve and understand it better.
85 citations
,
January 2007 in “Journal of Drug Targeting” Liposomes better deliver minoxidil for hair loss treatment than niosomes.
94 citations
,
September 2014 in “Therapeutic Delivery” Nanoparticles can improve skin treatments by better targeting hair follicles, but more research is needed for advancement.