Comparing the Delivery to the Hair Bulb of Two Fluorescent Molecules of Distinct Hydrophilicities by Different Nanoparticles and a Serum Formulation

The study compared the delivery of two fluorescent molecules, Nile Red (NR) and Nile Blue (NB), to the hair bulb using nanoparticle systems (liposomes, ethosomes, and polymeric nanoparticles) and a serum formulation. The nanoparticles showed high encapsulation efficiency, particularly liposomes and ethosomes with around 100% for both dyes, while polymeric nanoparticles had lower efficiencies. Stability tests over 6 months favored lipid-based nanoparticles. Despite the potential of nanoparticles, the serum formulation outperformed them in delivering both molecules to deeper follicular regions. The study concluded that serum formulations might be a better choice for targeting the hair bulb due to their simplicity and adaptability, although nanoparticles could be useful for specific needs. The number of participants or samples was not mentioned in the document.