Development and Evaluation of Finasteride-Loaded Ethosomes for Targeting the Pilosebaceous Unit

The article discusses the development and evaluation of finasteride-loaded ethosomes for targeting to the pilosebaceous unit (PSU) to treat androgenetic alopecia (AGA). The study aimed to prepare ethosomes of FIN with a size range 100-300 nm to enhance its delivery to the PSU. The results showed that finasteride loaded ethosomes (FES) were able to permeate across rat skin and frontal scalp skin of human cadaver when compared to the unencapsulated FIN. The study concluded that FES has the ability to permeate across the stratum corneum to reach the PSU of the hair follicle. Overall, the study found that finasteride-loaded ethosomes have potential for targeting the pilosebaceous unit and improving the efficacy of finasteride for treating hair loss.