Finasteride-Associated Male Infertility

December 2010 in “ Fertility and Sterility ”

Koji Chiba, Kohei Yamaguchi, Fuping Li, Makoto Ando, Masato Fujisawa

finasteride androgenic alopecia male infertility semen volume sperm concentration subfertility Propecia

Studysummary In this case report, a male patient's semen parameters improved after discontinuing a 1-mg dose of finasteride, suggesting that stopping the medication may benefit infertile men with previous sperm production issues.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

This document discusses a case study of a male patient who experienced infertility while taking finasteride for androgenic alopecia. After discontinuing the medication, the patient's semen volume and sperm concentration improved. The authors suggest that finasteride at a dose of 1 mg may have an adverse effect on male fertility in cases of pre-existing subfertility, and cessation of the drug could be taken into consideration in infertile male patients with impaired semen parameters who are taking finasteride at the 1-mg dose.

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research Effect of 1-Mg Dose of Finasteride on Spermatogenesis and Pregnancy

11 citations , March 2010 in “International Journal of Andrology”

This article reviews multiple entries on the Androlog blog regarding finasteride use, concluding that a 1-mg dose does not adversely affect spermatogenesis or pose a risk during conception or pregnancy.

research Propecia-Induced Spermatogenic Failure: A Report of Two Cases

49 citations , December 2007 in “Fertility and Sterility”

This case report describes two infertile patients who experienced significant improvements in sperm concentrations six months after stopping finasteride.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

research Finasteride-Associated Male Infertility

34 citations , January 2004 in “Revista do Hospital das Clínicas”

The authors reported that young men with infertility-related conditions experienced improved seminal quality after stopping finasteride, suggesting potential adverse effects on fertility during treatment.

research Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men

104 citations , October 1999 in “The Journal of Urology”

This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.