Propecia-Induced Spermatogenic Failure: A Report of Two Cases

December 2007 in “ Fertility and Sterility ”

Kimberly Liu, Saleh Binsaleh, Kirk Lo, Keith Jarvi

finasteride spermatogenic failure azoospermia sperm concentration semen parameters subfertility Propecia

Studysummary This case report describes two infertile patients who experienced significant improvements in sperm concentrations six months after stopping finasteride.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

research Finasteride-Associated Male Infertility

34 citations , January 2004 in “Revista do Hospital das Clínicas”

The authors reported that young men with infertility-related conditions experienced improved seminal quality after stopping finasteride, suggesting potential adverse effects on fertility during treatment.

research Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats

18 citations , May 2002 in “BJUI”

This study found that chronic exposure to finasteride did not significantly impact spermatogenesis in rats.

research Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men

104 citations , October 1999 in “The Journal of Urology”

This study concluded that daily treatment with 1 mg finasteride did not affect spermatogenesis or semen production in young men and had small, reversible effects on prostate volume and serum PSA.

research Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation

37 citations , January 1991 in “Reproductive Toxicology”

The study observed that finasteride reduced fertility in male Sprague-Dawley rats by impairing the formation of copulatory plugs, an effect considered specific to rats and not applicable to species without this reproductive feature.

research Reversible Decreases of Fertility in Male Sprague-Dawley Rats Treated Orally with Finasteride, a 5α-Reductase Inhibitor

28 citations , January 1991 in “Reproductive Toxicology”

Finasteride temporarily lowers male rat fertility without affecting libido.