Pregnancy Outcomes with Paternal Exposure to Finasteride, a Synthetic 5-Alpha-Reductase Inhibitor: A Case Series

    January 2015 in “ Journal of Clinical Toxicology ”
    Ahn Kh, Jawon Shin, Seong-Tshool Hong, Jiye Han, Eun-Ho Lee, Jae Sung Lee, Myung-Joo Oh, Hyung Jun Kim
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    TLDR Babies were mostly born healthy from fathers who took finasteride, but some pregnancies ended early; more research is needed.
    In a 2015 case series study from the Korean Motherisk Program involving 19 pregnant women whose partners were exposed to finasteride, a drug for male pattern baldness and benign prostatic hyperplasia, 68.4% (13 cases) resulted in normal full-term births, while 31.6% (6 cases) ended in spontaneous or artificial abortions. The study suggested a potential link between paternal finasteride exposure and adverse pregnancy outcomes, consistent with prior animal studies, but noted the need for further research due to limitations such as the lack of paternal sperm quality data and the small sample size. The authors recommended that men considering fatherhood should be cautious about using finasteride until more conclusive safety data is available.
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