TLDR New hybrid compound found to effectively prevent hair loss.
The paper reports on the discovery of a new hybrid compound that inhibits 5α-reductase, an enzyme involved in hair loss. The compound was found to be a potent inhibitor in low IC50 ranges and has potential as a therapeutic agent for the treatment of BPH. The study compared the inhibitory effects of the compound with finasteride and epristeride and concluded that the hybrid compound provides a novel template for the development of pharmacokinetically improved analogues.
Cited in this study
3 / 3 results
47 citations
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July 2009 in “Journal of Biological Chemistry” Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.
26 citations
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May 2000 in “Journal of The American Academy of Dermatology” Finasteride improves hair growth.
124 citations
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September 1992 in “Endocrinology” The human type II 5α-reductase gene, linked to certain male health conditions, has a specific structure and low similarity to other related genes.
18 citations
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January 2011 in “Bioorganic & Medicinal Chemistry Letters” New hybrid compound found to effectively prevent hair loss.
4 citations
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September 2010 in “Acta Biologica Hungarica” New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
136 citations
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March 1996 in “Journal of the American Chemical Society” Finasteride effectively blocks enzyme causing male pattern baldness.
