Intraethnic Variation in Steroid-5-Alpha-Reductase Polymorphisms in Prostate Cancer Patients: A Potential Factor Implicated in 5-Alpha-Reductase Inhibitor Treatment

    June 2015 in “ Journal of Genetics/Journal of genetics ”
    Luis Alberto Henríquez-Hernández, A. Valenciano, Palmira Foro Arnalot, María Jesús Álvarez-Cubero, J.M. Cózar, José Francisco Suárez-Novo, Manel Castells-Esteve, Pablo Fernández-Gonzalo, Belén De-Paula-Carranza, M. Ferrer, Ferrán Guedea, G. Sancho Pardo, Jordi Craven–Bartle, María José Ortiz-Gordillo, Patricia Cabrera-Roldán, Estefanía Herrera-Ramos, Carlos Rodríguez-Gallego, Pedro C. Lara
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    TLDR Genetic differences within ethnic groups may affect prostate cancer treatment effectiveness.
    The study investigated intraethnic variations in steroid-5-alpha-reductase polymorphisms among prostate cancer patients and explored how these variations might influence the effectiveness of 5-alpha-reductase inhibitor treatments. The research was supported by a grant from the Instituto de Salud Carlos III and the Instituto Canario de Investigacion del Cancer. The findings suggested that genetic differences within ethnic groups could be a significant factor in the variability of treatment responses, highlighting the importance of personalized medicine in managing prostate cancer.
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