Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period

    April 2012 in “ Fertility and Sterility ”
    Patrick Garcia, Mainara Ferreira Barbieri, Juliana Elaine Perobelli, Sílvio Roberto Consonni, Suzana de Fátima Paccola Mesquita, Wilma De Grava Kempinas, Luis S. Pereira
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    TLDR Finasteride causes lasting fertility decrease in rats.
    The study investigated the effects of finasteride on the epididymis and fertility in rats. The results showed that finasteride treatment caused morphometric-stereological and functional alterations in the epididymis, leading to a decrease in fertility. These effects persisted even after a 30-day post-treatment recovery period. The study suggests that finasteride may have negative effects on male reproductive health and fertility.
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