Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period

    April 2012 in “ Fertility and Sterility ”
    Patrick Garcia, Mainara Ferreira Barbieri, Juliana Elaine Perobelli, Sílvio Roberto Consonni, Suzana de Fátima Paccola Mesquita, Wilma De Grava Kempinas, Luis S. Pereira
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    TLDR Finasteride causes lasting fertility decrease in rats.
    The study investigated the effects of finasteride on the epididymis and fertility in rats. The results showed that finasteride treatment caused morphometric-stereological and functional alterations in the epididymis, leading to a decrease in fertility. These effects persisted even after a 30-day post-treatment recovery period. The study suggests that finasteride may have negative effects on male reproductive health and fertility.
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      Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

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