Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period

    April 2012 in “ Fertility and Sterility ”
    Patrick Garcia, Mainara Ferreira Barbieri, Juliana Elaine Perobelli … Luis S. Pereira
    Studysummary In this laboratory study with rats, treatment with finasteride reduced dihydrotestosterone levels and fertility parameters, with a 30-day recovery period proving insufficient to fully restore sperm function and fertility.
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    Research cited in this study 16

    1. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    2. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    3. Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia Archives of Dermatology · 2010
    4. Alopecia in Epidermolysis Bullosa Dermatologic Clinics · 2009
    5. Value of Hormonal Levels in Patients with Male Androgenetic Alopecia Treated with Finasteride: Better Response in Patients Under 26 Years Old British Journal of Dermatology · 2008
    6. The Rationale for Inhibiting 5α-Reductase Isoenzymes in the Prevention and Treatment of Prostate Cancer ˜The œJournal of urology/˜The œjournal of urology · 2008
    7. Propecia-Induced Spermatogenic Failure: A Report of Two Cases Fertility and Sterility · 2007
    8. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    9. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    10. Actions of 5α-Reductase Inhibitors on the Epididymis Molecular and Cellular Endocrinology · 2006
    11. Finasteride-Associated Male Infertility Revista do Hospital das Clínicas · 2004
    12. 5α-Reductase Activity in the Prostate Urology · 2001
    13. Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men The Journal of Urology · 1999
    14. Bone Density Is Normal in Male Rats Treated with Finasteride Endocrinology · 1995
    15. Decreased Fertility in Male Rats Administered the 5α-Reductase Inhibitor, Finasteride, Due to Deficits in Copulatory Plug Formation Reproductive Toxicology · 1991
    16. Reversible Decreases of Fertility in Male Sprague-Dawley Rats Treated Orally with Finasteride, a 5α-Reductase Inhibitor Reproductive Toxicology · 1991

    Related research 1

    1. Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period Fertility and Sterility · 2012