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research Morphometric-stereological and functional epididymal alterations and a decrease in fertility in rats treated with finasteride and after a 30-day post-treatment recovery period

20 citations , April 2012 in “Fertility and Sterility”

In this laboratory study with rats, treatment with finasteride reduced dihydrotestosterone levels and fertility parameters, with a 30-day recovery period proving insufficient to fully restore sperm function and fertility.

research Alterations of collagen type 1, skin fibroblasts, and macrophages in the scalp following the treatment of 1550‐nm erbium glass fractional laser for androgenetic alopecia

June 2021 in “Journal of Cosmetic Dermatology”

Laser treatment shows promise for hair growth, but needs further research.

research Polycystic Ovary Syndrome and Alteration of Vocal Function: A Systematic Review and Meta-Analysis

January 2024 in “Gynecologic and Obstetric Investigation”

This meta-analysis reported no significant differences in vocal alterations and quality of life between women with PCOS and control groups, yet emphasized that the findings are limited by a lack of high-quality studies, suggesting further research is needed.

research Modulation of Murine Hair Follicle Function by Alterations in Ornithine Decarboxylase Activity

71 citations , May 1996 in “Journal of Investigative Dermatology”

This study found that overexpression of a mutated ornithine decarboxylase transgene in mice led to complete hair loss, which could be prevented or reversed with an ODC inhibitor.

research Transcriptomics analysis reveals molecular alterations underpinning spaceflight dermatology

7 citations , June 2024 in “Communications Medicine”

In this study, researchers analyzed spaceflight data from various sources and found that skin issues during spaceflight are linked to DNA damage, mitochondrial dysregulation, and gene alterations, while also highlighting the skin's adaptability post-flight.

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community Dutasteride and TRT study indicates improvement in aging male symptoms and no difference between placebo group and dutasteride group

in Finasteride/Dutasteride 45 upvotes 1 month ago

Dutasteride is recommended for men on testosterone replacement therapy (TRT) with DHT-sensitive hair, as it does not interfere with TRT's anabolic effects and may improve libido and aging male symptoms. Users report varying experiences with libido when switching from finasteride to dutasteride, with some noticing improvements and others experiencing fluctuations.

community Amplifica: Hope or Cope? A Review of Their Pipeline

9 upvotes 1 month ago

Amplifica's AMP-303 showed a modest increase in hair growth, but results were inconsistent and potentially misleading. Hyaluronic acid and osteopontin are being explored for hair growth, with varying effects on different hair types and conditions.

community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community Microneedling at .25 everyday before applying Min

in Minoxidil 26 upvotes 1 year ago

Daily microneedling at 0.25mm before applying minoxidil is debated, with some suggesting weekly microneedling is safer and more effective. Concerns include potential skin damage and systemic absorption, while alternatives like tretinoin are considered safer for enhancing minoxidil absorption.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

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Learn

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learn Glycerin

Does topical glycerin have any effect on hair thickness or follicle function? Topical glycerin mainly hydrates the hair and scalp; no study has shown that it increases hair thickness or changes follicle function.

learn Selenium

What is Selenium and why is it important for healthy hair and scalp function? Selenium is a trace mineral the body needs, but extra selenium has not been shown to help hair in people who are not deficient. Too much (above the US upper limit of 400 µg a day) can cause hair loss.

learn Thymosin Beta 4

What is Thymosin Beta 4, and why is it being researched in relation to hair follicle function and regeneration? Thymosin beta-4 is a natural peptide whose effect on hair has been studied only in mice, rats and cells; there are no human trials. It is not approved for hair loss, and the FDA flags its grey-market form, TB-500, for safety risks.

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