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Glossaryepididymis

coiled tube storing and maturing sperm cells

The epididymis is a coiled tube located at the back of the testicle that stores and carries sperm. It plays a crucial role in the maturation of sperm cells, allowing them to gain the ability to swim and fertilize an egg.

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Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

research Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

13 citations, August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology”

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

research Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

2 citations, September 2017 in “Archives of Medical Science”

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

research Hairless or Fertile? Finasteride Leads to Epididymal Changes and Infertility in Rats

3 citations, April 2012 in “Fertility and Sterility”

Finasteride may cause infertility in rats by affecting epididymis and sperm function.

research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility

35 citations, October 2004 in “Biology of Reproduction”

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.

Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period

research Morphometric-Stereological and Functional Epididymal Alterations and a Decrease in Fertility in Rats Treated with Finasteride and After a 30-Day Post-Treatment Recovery Period

20 citations, April 2012 in “Fertility and Sterility”

Finasteride causes lasting fertility decrease in rats.

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community DHT Isn't (Directly) Important

in Research/Science 99 upvotes 1 month ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community Ejaculation & balding: NoFap has helped me stop my hair loss [case study]

37 upvotes 8 years ago

The user claims NoFap (abstaining from pornography, masturbation, and orgasm) helped stop their hair loss. Others argue that hair loss is primarily due to genetics and DHT, which can be managed with finasteride.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 1 year ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 1 year ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

in Research/Science 8 upvotes 3 months ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.