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Glossaryepididymis

coiled tube storing and maturing sperm cells

The epididymis is a coiled tube located at the back of the testicle that stores and carries sperm. It plays a crucial role in the maturation of sperm cells, allowing them to gain the ability to swim and fertilize an egg.

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Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

research Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates

13 citations , August 1995 in “The Journal of Steroid Biochemistry and Molecular Biology”

The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.

research Epididymis in an Experimental Model of DHT Deficiency: Immunolocalization of ERalpha and ERbeta in Rat Epididymal Epithelial Cells. In Vivo and In Vitro Studies

4 citations , January 2006 in “PubMed”

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

research Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

2 citations , September 2017 in “Archives of Medical Science”

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

research Equine 5α-Reductase Activity and Expression in Epididymis

14 citations , July 2016 in “Journal of Endocrinology”

The equine epididymis mainly uses type 1 5α-reductase, and both finasteride and dutasteride can inhibit its activity.

research Morphology of the Testis and the Epididymis in Rats with Dihydrotestosterone Deficiency

34 citations , January 2004 in “PubMed”

DHT deficiency in rats reduces sperm content and affects testis structure over time.

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community DHT Isn't (Directly) Important

in Research/Science 98 upvotes 9 months ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community Ejaculation & balding: NoFap has helped me stop my hair loss [case study]

37 upvotes 8 years ago

The user claims NoFap (abstaining from pornography, masturbation, and orgasm) helped stop their hair loss. Others argue that hair loss is primarily due to genetics and DHT, which can be managed with finasteride.

community Creatine is the opposite of minoxidil !

in Research/Science 319 upvotes 1 month ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 1 year ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

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