Hairless or Fertile? Finasteride Leads to Epididymal Changes and Infertility in Rats

    April 2012 in “ Fertility and Sterility
    Keith Jarvi
    Image of study
    TLDR Finasteride may cause infertility in rats by affecting epididymis and sperm function.
    The use of finasteride, a 5 a-reductase inhibitor commonly used to treat male baldness, may lead to epididymal changes and infertility in rats, according to a study by Garcia et al. The study found that finasteride caused changes in the structure and function of the epididymis, as well as reduced sperm function and fertility potential without any significant alterations in sperm production. The authors postulated that the poorer sperm parameters and fertility potential in those rats treated with finasteride were due in part to the rapid transit through the epididymis. The study adds experimental weight to the limited literature suggesting that the use of finasteride could result in male infertility.
    Discuss this study in the Community →

    Research cited in this study

    5 / 5 results

    Related Community Posts Join

    6 / 1000+ results

      community New and Interesting HairLoss Studies/Papers/Reviews

      in Treatment  44 upvotes 5 years ago
      Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 7 months ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community Just popped my first fin, excited as hell!

      in Finasteride/Dutasteride  154 upvotes 10 months ago
      A user shared their excitement about starting finasteride for hair loss after trying various ineffective methods. Other users discussed their experiences with finasteride, including shedding phases and side effects, with one mentioning using topical finasteride and minoxidil.

      community All my gains from minoxidil fell out years later

      in Finasteride/Dutasteride  48 upvotes 1 month ago
      The user experienced hair loss after initially gaining hair with minoxidil and is now using dutasteride and oral minoxidil alongside topical minoxidil, hoping to regain lost hair. There is uncertainty about the effectiveness of these treatments, with some users suggesting that blocking DHT might help, while others express skepticism about regrowth.

    Similar Research

    5 / 1000+ results