Effects of Dermatological Medications on Male Fertility

The document reviewed the effects of various dermatological medications on male fertility, finding that methotrexate, finasteride, and ketoconazole could impair fertility, with recommendations for discontinuation before conception attempts. Oral retinoids, cyclosporine, azathioprine, and TNF-α inhibitors did not adversely affect fertility. There was limited and conflicting evidence for the effects of glucocorticoids, TNF-α inhibitors, acitretin, isotretinoin, antibiotics, spironolactone, chloroquine, and antihistamines, leading to no clear recommendations for their withdrawal. The review emphasized the importance of counseling male patients on the potential reversible effects of these medications on fertility.