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GlossaryAzathioprine

immunosuppressive drug used to treat autoimmune diseases and alopecia

Azathioprine, also known by brand names such as Imuran, is an immunosuppressive medication commonly used to prevent organ rejection in transplant patients and to treat autoimmune conditions like rheumatoid arthritis and certain types of alopecia. It works by inhibiting the proliferation of immune cells, thereby reducing the immune system's activity and preventing it from attacking the body's own tissues.

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research Efficacy and Tolerability of Azathioprine for Neuromyelitis Optica Spectrum Disorder: A Systematic Review and Meta-Analysis

54 citations, May 2019 in “Multiple Sclerosis and Related Disorders”

Azathioprine can help with relapses and disability in NMOSD but has more side effects and needs more research.

research Azathioprine

42 citations, January 1998 in “BioDrugs”

Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.

research Adverse Events Associated with Azathioprine Treatment in Korean Pediatric Inflammatory Bowel Disease Patients

16 citations, January 2013 in “Pediatric Gastroenterology Hepatology & Nutrition”

Azathioprine caused side effects in over half of the Korean pediatric inflammatory bowel disease patients, requiring close monitoring.

Utility of Azathioprine, Methotrexate, and Cyclosporine as Steroid-Sparing Agents in Chronic Alopecia Areata: A Retrospective Study of Continuation Rates in 138 Patients

research Utility of Azathioprine, Methotrexate, and Cyclosporine as Steroid-Sparing Agents in Chronic Alopecia Areata: A Retrospective Study of Continuation Rates in 138 Patients

12 citations, August 2020 in “JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology”

Azathioprine is the most continued treatment for chronic alopecia areata over a year, often with added low-dose prednisolone.

NUDT15 Polymorphism Explains Serious Toxicity to Azathioprine in Indian Patients With Chronic Immune Thrombocytopenia and Autoimmune Hemolytic Anemia: A Case Series

research NUDT15 Polymorphism Explains Serious Toxicity to Azathioprine in Indian Patients With Chronic Immune Thrombocytopenia and Autoimmune Hemolytic Anemia: A Case Series

10 citations, August 2020 in “Drug metabolism and drug interactions”

The NUDT15 gene variant causes severe side effects from azathioprine in some Indian patients.

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