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Glossary Chloroquine

medication used to treat malaria and autoimmune diseases

Chloroquine is a medication primarily used to prevent and treat malaria, a disease caused by parasites transmitted through mosquito bites. It has also been used to treat autoimmune diseases like rheumatoid arthritis and lupus due to its anti-inflammatory properties. In recent years, it gained attention for its potential use in treating COVID-19, although its efficacy for this purpose remains controversial.

Research

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research Pharmacological evidence for the involvement of adenosine triphosphate sensitive potassium channels in chloroquine-induced itch in mice

9 citations , June 2017 in “Pharmacological Reports”

This study found that ATP-sensitive potassium channels may play a role in chloroquine-induced itching in mice, as channel openers reduced scratching behavior while a blocker reversed these effects.

research Chloroquine and cinchonine affect rat vascular smooth muscle tonus through calcium channels – in silico and in vitro approaches

January 2024 in “Bratislavské lekárske listy/Bratislava medical journal”

This study examined the vasorelaxant effects of two similar alkaloids, chloroquine and cinchonine, in a model of smooth muscle contractions induced by phenylephrine. Results are not reported in the abstract.

research Hydroxychloroquine and Chloroquine in Prophylaxis and Treatment of COVID-19

2 citations , October 2020 in “Journal of Pharmacy And Bioallied Sciences”

This study reviewed existing literature on chloroquine and hydroxychloroquine's safety and efficacy in COVID-19 management, finding mixed clinical evidence and highlighting the need for more rigorous trials to determine their potential role in treatment.

research Chemogenetic inhibition of Grpr- and/or Npff- expressing spinal neurons in mice suppresses chloroquine-evoked itch, but not signs of mechanical allodynia in a neuropathic pain model

April 2026 in “ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)”

research A subpopulation of itch‐sensing neurons marked by Ret and somatostatin expression

70 citations , February 2016 in “EMBO reports”

This study identified a subtype of itch-sensing neurons in mice, which express Ret and somatostatin, and found that their ablation reduces scratching induced by certain pruritogens.

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