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    Glossary Methotrexate

    inhibits cell growth by blocking folic acid metabolism

    Methotrexate (MTX) is a medication commonly used to treat certain types of cancer, autoimmune diseases like rheumatoid arthritis, and severe psoriasis. It works by inhibiting the metabolism of folic acid, which is necessary for the rapid growth of cells, thereby slowing down the proliferation of cancer cells and modulating the immune system.

    Research 10 of 1000+

    1. The pharmacology of methotrexate Journal of The American Academy of Dermatology · 1991 · 155 citations
    2. Methotrexate in the treatment of steroid-dependent asthma 1991 · 80 citations
    3. Methotrexate in dermatology Dermatologic Therapy · 2007 · 77 citations
    4. Efficacy and tolerability of methotrexate in severe childhood alopecia areata 2011 · 70 citations
    5. Methotrexate for induction of remission in ulcerative colitis Cochrane library · 2014 · 53 citations
    6. Methotrexate for maintenance of remission in ulcerative colitis Cochrane library · 2015 · 51 citations
    7. Efficacy and safety of methotrexate in alopecia areata 2014 · 44 citations
    8. Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR , TYMS, and TCII genes and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis Polskie Archiwum Medycyny Wewnętrznej · 2015 · 42 citations
    9. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012 · 39 citations
    10. Efficacy and Safety of Methotrexate Combined with Low- to Moderate-Dose Corticosteroids for Severe Alopecia Areata Dermatology · 2016 · 28 citations
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