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    Glossary Methotrexate

    inhibits cell growth by blocking folic acid metabolism

    Methotrexate (MTX) is a medication commonly used to treat certain types of cancer, autoimmune diseases like rheumatoid arthritis, and severe psoriasis. It works by inhibiting the metabolism of folic acid, which is necessary for the rapid growth of cells, thereby slowing down the proliferation of cancer cells and modulating the immune system.

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    1. The pharmacology of methotrexate Journal of The American Academy of Dermatology · 1991 · 155 citations
    2. Methotrexate in the treatment of steroid-dependent asthma 1991 · 80 citations
    3. Methotrexate in dermatology Dermatologic Therapy · 2007 · 77 citations
    4. Efficacy and tolerability of methotrexate in severe childhood alopecia areata 2011 · 70 citations
    5. Methotrexate for induction of remission in ulcerative colitis Cochrane library · 2014 · 53 citations
    6. Methotrexate for maintenance of remission in ulcerative colitis Cochrane library · 2015 · 51 citations
    7. Efficacy and safety of methotrexate in alopecia areata 2014 · 44 citations
    8. Associations between single-nucleotide polymorphisms of RFC-1, GGH, MTHFR , TYMS, and TCII genes and the efficacy and toxicity of methotrexate treatment in patients with rheumatoid arthritis Polskie Archiwum Medycyny Wewnętrznej · 2015 · 42 citations
    9. Interest of High-Dose Pulse Corticosteroid Therapy Combined with Methotrexate for Severe Alopecia Areata: A Retrospective Case Series Dermatology · 2012 · 39 citations
    10. Efficacy and Safety of Methotrexate Combined with Low- to Moderate-Dose Corticosteroids for Severe Alopecia Areata Dermatology · 2016 · 28 citations
    11. Methotrexate in Severe Childhood Alopecia Areata: Long-term Follow-up Acta dermato-venereologica · 2015 · 25 citations
    12. METHOTREXATE FOR GENERALIZED PUSTULAR PSORIASIS IN A 2-YEAR-OLD CHILD Pediatric Dermatology · 2005 · 25 citations
    13. Patient’s experience with subcutaneous and oral methotrexate for the treatment of rheumatoid arthritis BMC musculoskeletal disorders · 2016 · 23 citations
    14. Methotrexate for the treatment of pediatric alopecia areata Journal of dermatological treatment · 2017 · 22 citations
    15. Acute Bullous Dermatosis and Onycholysis due to High-Dose Methotrexate and Leucovorin Calcium Archives of Dermatology · 1987 · 21 citations
    16. High‐dose pulsed corticosteroid therapy combined with methotrexate for severe alopecia areata of childhood 2017 · 15 citations
    17. Inhibition of Established Tuberculin Hypersensitivity by Methptrexate, Experimental Biology and Medicine · 1964 · 15 citations
    18. Low-Dose Systemic Methotrexate Therapy for Recalcitrant Alopecia Areata Annals of Dermatology · 2017 · 14 citations
    19. The effect of active hexose correlated compound in modulating cytosine arabinoside-induced hair loss, and 6-mercaptopurine- and methotrexate-induced liver injury in rodents Cancer epidemiology · 2009 · 14 citations
    20. Utility of azathioprine, methotrexate and cyclosporine as steroid‐sparing agents in chronic alopecia areata: a retrospective study of continuation rates in 138 patients 2020 · 12 citations
    21. Is methotrexate an effective and safe treatment for maintaining hair regrowth in people with alopecia totalis? A Critically Appraised Topic 2018 · 12 citations
    22. [Methotrexate to treat SAPHO syndrome with keloidal scars]. PubMed · 2011 · 10 citations
    23. Methotrexate treatment of generalized granuloma annulare: a retrospective case series Journal of dermatological treatment · 2018 · 9 citations
    24. Clinical Profile of Methotrexate-resistant Juvenile Localised Scleroderma Acta dermato-venereologica · 2019 · 8 citations
    25. Methotrexate-associated lymphoproliferative disorder: Sequential development of angioimmunoblastic T-cell lymphoma-like lymphoproliferation in the lymph nodes and diffuse large B-cell lymphoma in the skin in the same patient European Journal of Dermatology · 2015 · 6 citations
    26. Hyperpigmentation, severe alopecia, and six days of instability in a case of severe methotrexate hypersensitivity reaction Daru · 2021 · 5 citations
    27. The Influence of Race and Sex on the Side Effect Profile of Methotrexate in the Treatment of Uveitis Ocular immunology and inflammation · 2018 · 5 citations
    28. A rare case of multiple keratoacanthomas treated with oral acitretin and intralesional methotrexate Indian dermatology online journal · 2016 · 5 citations
    29. Comparative Efficacy Study Combination of Oral Methotrexate and Prednisolone versus Oral Methotrexate in Patients with Lichen Planopilaris Dermatology Research and Practice · 2022 · 4 citations
    30. Frontal Fibrosing Alopecia: Successfully Treated with Methotrexate or Just the Natural Disease Progression? 2020 · 4 citations