Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

September 2017 in “ Archives of Medical Science ”

Agnieszka Kolasa, Maciej Tarnowski, Irena Baranowska-Bosiacka, Dariusz Chlubek, Barbara Wiszniewska

finasteride antioxidant enzyme mRNA protein epididymis androgens reactive oxygen species ROS epididymal epithelial cells post-testicular spermatozoa maturation Propecia RNA hormones epididymal cells sperm maturation

TLDR Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

The study investigated the effects of finasteride on antioxidant enzyme expression in the epididymis of male rat offspring during postnatal development. The results showed that finasteride treatment of parental rats resulted in changes in their offspring, including changes in antioxidant enzyme expression in the epididymis at mRNA and protein levels, immunolocalization of the enzymes in epididymal epithelial cells, and correlations between serum androgens and transcripts of antioxidant enzymes in finasteride-treated male offspring compared to controls. These changes could disturb the epididymal microenvironment, such as the antioxidant defense system and concentration of ROS, which are needed for correct post-testicular spermatozoa maturation.

View this study on archivesofmedicalscience.com →

Discuss this study in the Community →

Research cited in this study

8 / 8 results

research Connexin 43 Expression in the Testes During Postnatal Development of Finasteride-Treated Male Rat Offspring

3 citations , February 2017 in “Archives of Medical Science”

Finasteride treatment changes Cx43 in rat testes, possibly causing fertility issues.

research Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring

10 citations , September 2015 in “Folia Histochemica Et Cytobiologica”

Finasteride treatment in male rats can reduce fertility and affect sperm development in their offspring.

research DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

DHT deficiency can disrupt cell connections in rat testes, possibly affecting fertility.

research The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency

28 citations , January 2009 in “Cellular & Molecular Biology Letters”

DHT deficiency increases iNOS expression in rat testis and epididymis.

research Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats

10 citations , September 2008 in “Andrologia”

Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.

Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

research Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

77 citations , October 2007 in “International Journal of Andrology”

Testosterone with or without finasteride doesn't improve thinking skills in older men with low testosterone.

research Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities

51 citations , February 2004 in “Environmental Health Perspectives”

Control variability makes it hard to confirm low-dose endocrine effects.

research Morphology of the Testis and the Epididymis in Rats with Dihydrotestosterone Deficiency

34 citations , January 2004 in “PubMed”

DHT deficiency in rats reduces sperm content and affects testis structure over time.

Related Community Posts Join

6 / 1000+ results

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community The theory that explains everything. Please help me make this big!

in Research/Science 2450 upvotes 4 years ago

The post and conversation are about the role of the enzyme 3alpha-hydroxysteroid reductase in hair loss and the potential of compounds like procyanidin B2 and sulforaphane to boost its activity for hair regrowth. Further research is needed to develop effective treatments based on this theory.

community Bryan Johnson just dropped his anti hair loss formula

in Treatment 340 upvotes 1 year ago

Bryan Johnson shared his hair loss treatment, which mainly relies on minoxidil and finasteride. Some users are skeptical of his results, while others appreciate his efforts in anti-aging and hair loss research.

community How I recovered from 4+ years of severe balding ages 20-24 by dieting, lifestyle changes and ONLY using topical minoxidil

in Progress Pictures 473 upvotes 3 months ago

A user reversed severe hair loss with dieting, lifestyle changes, and topical minoxidil, highlighting reduced inflammation and body fat. The conversation debates finasteride's effectiveness and the impact of diet and lifestyle on hair health.

community Nice product I discovered, thought I would share.

in Treatment 456 upvotes 7 months ago

A product that makes hair look thicker and healthier without promoting regrowth. Discussions include treatments like minoxidil, finasteride, red light therapy, and a serum with caffeine and peptides, with mixed effectiveness opinions.

community u/joaopassos4444 has zero education in endocrinology, human biology or science, it’s incredibly unlikely he good Will Hunting-ed a medical issue that stumped researchers for thousands of years, please stop buying random supplements based on layman speculation and temper your expectations

in Research/Science 69 upvotes 4 years ago

User questions credibility of a hair loss "cure" found by a non-expert and warns against wasting money on unproven supplements. Others discuss trying natural extracts and the importance of researching the enzyme 3ADH for potential hair growth benefits.

Related Research

1 / 1 results

research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility

35 citations , October 2004 in “Biology of Reproduction”

PNU157706 reduced rat sperm movement and fertility without affecting offspring health.