Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

    September 2017 in “ Archives of Medical Science ”
    Agnieszka Kolasa, Maciej Tarnowski, Irena Baranowska-Bosiacka … Barbara Wiszniewska
    Studysummary The researchers reported that finasteride treatment in male rats may lead to changes in antioxidant enzyme activity in their offspring's epididymis, potentially affecting sperm maturation.
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    Research cited in this study 8

    1. Connexin 43 Expression in the Testes During Postnatal Development of Finasteride-Treated Male Rat Offspring Archives of Medical Science · 2017
    2. Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring Folia Histochemica Et Cytobiologica · 2015
    3. DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions Folia Histochemica et Cytobiologica · 2011
    4. The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency Cellular & Molecular Biology Letters · 2009
    5. Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats Andrologia · 2008
    6. Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone International Journal of Andrology · 2007
    7. Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities Environmental Health Perspectives · 2004
    8. Morphology of the Testis and the Epididymis in Rats with Dihydrotestosterone Deficiency PubMed · 2004

    Related research 1

    1. Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility Biology of Reproduction · 2004