Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

September 2017 in “ Archives of Medical Science ”

Agnieszka Kolasa, Maciej Tarnowski, Irena Baranowska-Bosiacka, Dariusz Chlubek, Barbara Wiszniewska

finasteride antioxidant enzyme mRNA protein epididymis androgens reactive oxygen species ROS epididymal epithelial cells post-testicular spermatozoa maturation Propecia RNA hormones epididymal cells sperm maturation

Studysummary The researchers reported that finasteride treatment in male rats may lead to changes in antioxidant enzyme activity in their offspring's epididymis, potentially affecting sperm maturation.

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Research cited in this study

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research Connexin 43 Expression in the Testes During Postnatal Development of Finasteride-Treated Male Rat Offspring

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This study found that finasteride treatment in male rats may lead to changes in connexin 43 expression in the testes of their offspring, potentially affecting spermatogenesis.

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research DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

research The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency

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This study concluded that finasteride-induced DHT deficiency intensified constitutive iNOS expression in rat testicular and epididymal cells, suggesting a complex regulatory relationship needing further investigation.

research Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats

10 citations , September 2008 in “Andrologia”

In this study, treatment with finasteride altered the expression patterns of antioxidant enzymes in the epididymis of rats, potentially affecting its protective function for spermatozoa.

Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

research Exogenous Testosterone Alone or With Finasteride Does Not Improve Measurements of Cognition in Healthy Older Men With Low Serum Testosterone

77 citations , October 2007 in “International Journal of Andrology”

This study found that testosterone replacement, with or without finasteride, did not lead to significant cognitive improvements over 36 months in healthy older men without prior cognitive impairment.

research Natural Variability and the Influence of Concurrent Control Values on the Detection and Interpretation of Low-Dose or Weak Endocrine Toxicities

51 citations , February 2004 in “Environmental Health Perspectives”

This article analyzes various cases of weak or low-dose endocrine effects in laboratory animals and highlights challenges in data interpretation due to variability among controls, but reports no new experimental findings.

research Morphology of the Testis and the Epididymis in Rats with Dihydrotestosterone Deficiency

34 citations , January 2004 in “PubMed”

In this study, finasteride treatment for 56 days in adult rats led to sloughing of immature germinal cells and reduced sperm content in the epididymis, indicating its importance for maintaining spermatogenesis.