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Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

research Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

2 citations , September 2017 in “Archives of Medical Science”

Finasteride affects offspring's antioxidant enzymes in epididymis, possibly disrupting sperm maturation.

research Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats

10 citations , September 2008 in “Andrologia”

Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.

research Epididymis in an Experimental Model of DHT Deficiency: Immunolocalization of ERalpha and ERbeta in Rat Epididymal Epithelial Cells. In Vivo and In Vitro Studies

4 citations , January 2006 in “PubMed”

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

research Actions of 5α-Reductase Inhibitors on the Epididymis

48 citations , February 2006 in “Molecular and Cellular Endocrinology”

5α-reductase inhibitors may reduce male fertility and could be used for male contraception.

Analysis of the Expression Pattern of the Carrier Protein Transthyretin and Its Receptor Megalin in the Human Scalp Skin and Hair Follicles: Hair Cycle-Associated Changes

research Analysis of the Expression Pattern of the Carrier Protein Transthyretin and Its Receptor Megalin in the Human Scalp Skin and Hair Follicles: Hair Cycle-Associated Changes

6 citations , November 2010 in “Histochemistry and cell biology”

The proteins transthyretin and megalin are more present in the growth phase of hair, suggesting they might affect hair health and growth.

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Community Join

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community Topical Finasteride Doesn't Directly Reduce 5ar Enzyme on Scalp

in Finasteride/Dutasteride 72 upvotes 2 years ago

Topical Finasteride doesn't directly reduce 5ar enzyme on scalp and has the same mechanism as oral, needing to go through the liver. Users debate the accuracy of this information and discuss various studies and experiences.

community Quit vaping/smoking = 80% less loss

in Research/Science 235 upvotes 1 year ago

Quitting vaping significantly reduced hair loss for a user who was a heavy vaper and also taking finasteride. Some participants suggest nicotine's vasoconstrictive properties may worsen hair loss, while others share personal anecdotes of hair improvement after quitting smoking or vaping.

community Creatine is the opposite of minoxidil !

in Research/Science 322 upvotes 4 months ago

Creatine may counteract minoxidil's hair growth effects by closing potassium ATP channels, potentially leading to hair loss in predisposed individuals. Despite anecdotal reports, there is no conclusive evidence linking creatine to hair loss.

community DHT Isn't (Directly) Important

in Research/Science 98 upvotes 1 year ago

Finasteride's potential side effects, especially sexual dysfunction, are discussed, with emphasis on hormonal balance between testosterone and estradiol. Users share experiences with finasteride, minoxidil, and dutasteride, highlighting the variability in side effects and the influence of mindset and lifestyle.

community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

in Research/Science 10 upvotes 1 year ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

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