Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats

    October 2008 in “ Andrologia ”
    A. Kolasa, Mariola Marchlewicz, Gail K. Adler, Andrzej Ciechanowicz, Wojciech Głabowski, Barbara Wiszniewska
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    TLDR Finasteride changes antioxidant enzyme expression, possibly affecting sperm protection in rats.
    The study investigated the effects of finasteride, a steroid-based inhibitor of 5α-reductase, on the expression of antioxidant enzymes in the epididymal epithelial cells of rats. The researchers found that treatment with finasteride altered the pattern of expression of antioxidant enzymes, including Cu/Zn superoxide dismutase (Cu/ZnSOD), extracellular superoxide dismutase (E-SOD), and epididymal specific glutathione peroxidase 5 (GPX5), in the caput and cauda epididymis of rats. The study suggests that finasteride may alter the protective function of the epididymis in relation to spermatozoa.
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