The Effect of Finasteride on the Secretion of Testosterone, DHT, LH, FSH, and Tissue Factors in the Testis of NMRI Mice
June 2021
in “
Archives of Advances in Biosciences
”
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Studysummary This study suggests that finasteride at doses of 5 mg/kg BW or higher may adversely affect spermatogenesis and male fertility in NMRI mice.
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The study examined the impact of finasteride on male fertility and hormone levels in NMRI mice, with groups receiving 1, 5, and 20 mg/kg body weight (BW) of finasteride for 35 days. Significant reductions in dihydrotestosterone (DHT) were observed across all doses, while testosterone levels increased at 5 and 20 mg/kg BW. Both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels decreased significantly in finasteride-treated groups. Adverse effects on spermatogenesis were noted, particularly at 5 and 20 mg/kg BW, with a marked decrease in sperm count and motility, and a significant reduction in primary spermatocytes, spermatids, and spermatozoids. Spermatogonial cells were notably affected at the highest dose of 20 mg/kg BW. The study concluded that finasteride at doses of 5 mg/kg BW and above could negatively impact male reproductive capabilities.
