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research Effects of PNU157706, a Dual 5α-Reductase Inhibitor, on Rat Epididymal Sperm Maturation and Fertility1

35 citations , October 2004 in “Biology of Reproduction”

This study found that dual 5α-reductase inhibition in rats led to decreased sperm motility and altered morphology, resulting in subfertility.

Antioxidant Enzyme Expression of mRNA and Protein in the Epididymis of Finasteride-Treated Male Rat Offspring During Postnatal Development

research Antioxidant enzyme expression of mRNA and protein in the epididymis of finasteride-treated male rat offspring during postnatal development

2 citations , September 2017 in “Archives of Medical Science”

The researchers reported that finasteride treatment in male rats may lead to changes in antioxidant enzyme activity in their offspring's epididymis, potentially affecting sperm maturation.

Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

research Biochemical and Structural Characteristics, Gene Regulation, Physiological, Pathological and Clinical Features of Lipocalin-Type Prostaglandin D2 Synthase as a Multifunctional Lipocalin

18 citations , October 2021 in “Frontiers in Physiology”

This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.

research Determination of concentrations of sex steroids in blood plasma and semen of male dogs treated with delmadinone acetate or finasteride.

4 citations , January 2001 in “PubMed”

This study found that delmadinone acetate and finasteride caused a reversible suppression of prostate gland activity in male dogs, with delmadinone acetate also temporarily altering epididymal sperm maturation.

research Actions of 5α-reductase inhibitors on the epididymis

48 citations , February 2006 in “Molecular and Cellular Endocrinology”

This study found that dual 5α-reductase inhibitors in rats decreased sperm quality and led to reduced pregnancy success, suggesting potential for use in male contraception.

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community Possible transgenerational effects of finasteride use on male offspring? (STUDY)

in Research/Science 27 upvotes 4 months ago

Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.

community Haunting study is making me considering cycling fin/dut

in Research/Science 158 upvotes 1 year ago

Concerns about the long-term effects of dutasteride and finasteride on fertility, with discussions on cycling these medications to mitigate risks. The conversation highlights skepticism about study methodologies and the importance of weighing treatment risks against potential fertility issues.

community [23M] 1.5 year update. Minoxidil+derma roller+hair oil

in Progress Pictures 13 upvotes 2 years ago

A user shared their 1.5-year experience using Minoxidil, a derma roller, and hair oil for hair loss, noting significant improvements in hair health and density. They also emphasized the importance of a healthier lifestyle and the positive impact of using a product combining Minoxidil with plant extracts.

community Dutasteride causing us to have… girl babies?

in Finasteride/Dutasteride 26 upvotes 3 years ago

User Kylo313 used dutasteride for 20 years and had two daughters, questioning if dutasteride affects the likelihood of having male vs female children. Replies mostly request hairline photos and discuss anecdotal experiences, with some suggesting correlation doesn't imply causation and that gender determination isn't affected by dutasteride.

community how do you produce more thick white cum while on fin?

in Finasteride/Dutasteride 139 upvotes 5 months ago

Finasteride can reduce semen volume due to prostate shrinkage but doesn't affect fertility. To increase semen volume, consider zinc, lecithin, and reducing finasteride dosage.

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