Finasteride Use in the Male Infertility Population: Effects on Semen and Hormone Parameters

    September 2013 in “ Fertility and Sterility ”
    Mary K. Samplaski, Kirk C. Lo, Ethan D. Grober, Keith Jarvi
    Studysummary This study found that discontinuing finasteride led to a significant increase in sperm counts for most men with reduced fertility, though hormone levels and other semen parameters remained unchanged.
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    Research cited in this study 11

    1. Six Novel Susceptibility Loci for Early-Onset Androgenetic Alopecia and Their Unexpected Association with Common Diseases PLOS Genetics · 2012
    2. Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage Fertility and Sterility · 2011
    3. Finasteride-Associated Male Infertility Fertility and Sterility · 2010
    4. Effect of 1-Mg Dose of Finasteride on Spermatogenesis and Pregnancy International Journal of Andrology · 2010
    5. Male-Pattern Baldness Susceptibility Locus at 20p11 Nature Genetics · 2008
    6. Propecia-Induced Spermatogenic Failure: A Report of Two Cases Fertility and Sterility · 2007
    7. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    8. Actions of 5α-Reductase Inhibitors on the Epididymis Molecular and Cellular Endocrinology · 2006
    9. 5α-Reductase Activity in the Prostate Urology · 2001
    10. Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men The Journal of Urology · 1999
    11. Bone Density Is Normal in Male Rats Treated with Finasteride Endocrinology · 1995