Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia

    April 2015 in “ Current Opinion in Endocrinology, Diabetes and Obesity ”
    Michael S. Irwig
    Studysummary This review discusses the potential persistent adverse effects associated with 5α reductase inhibitor treatment for androgenetic alopecia but provides no new clinical results; it emphasizes the importance of discussing these risks with patients.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 21

    1. A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long-Term Side Effects After Finasteride Discontinuation International Journal of Biological Markers · 2014
    2. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia PLOS ONE · 2014
    3. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    4. Finasteride Use in the Male Infertility Population: Effects on Semen and Hormone Parameters Fertility and Sterility · 2013
    5. Long-Term Oral Administration of 5α-Reductase Inhibitor Attenuates Erectile Function by Inhibiting Autophagy and Promoting Apoptosis of Smooth Muscle Cells in Corpus Cavernosum of Aged Rats Urology · 2013
    6. Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report Alcoholism: Clinical and Experimental Research · 2013
    7. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    8. Incomplete Recovery of Erectile Function in Rats After Discontinuation of Dual 5-Alpha Reductase Inhibitor Therapy The Journal of Sexual Medicine · 2012
    9. Effects of Oral Finasteride on Erectile Function in a Rat Model The Journal of Sexual Medicine · 2012
    10. Alteration of Ethanol Drinking in Mice via Modulation of the GABAA Receptor with Ganaxolone, Finasteride, and Gaboxadol Alcoholism: Clinical and Experimental Research · 2011
    11. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    12. Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage Fertility and Sterility · 2011
    13. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    14. Inhibition of 5α-Reduced Steroid Biosynthesis Impedes Acquisition of Ethanol Drinking in Male C57BL/6J Mice Alcoholism Clinical and Experimental Research · 2008
    15. Propecia-Induced Spermatogenic Failure: A Report of Two Cases Fertility and Sterility · 2007
    16. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    17. Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study Archives of Andrology · 2007
    18. The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride Journal of The American Academy of Dermatology · 2006
    19. Finasteride-Associated Male Infertility Revista do Hospital das Clínicas · 2004
    20. Chronic Treatment with Finasteride Daily Does Not Affect Spermatogenesis or Semen Production in Young Men The Journal of Urology · 1999
    21. Finasteride in the Treatment of Men with Androgenetic Alopecia Journal of The American Academy of Dermatology · 1998

    Related research 1

    1. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992