A Pharmacogenetic Survey of Androgen Receptor (CAG)N and (GGN)N Polymorphisms in Patients Experiencing Long-Term Side Effects After Finasteride Discontinuation

September 2014 in “ International Journal of Biological Markers ”

Erika Cecchin, Elena De Mattia, Giorgio Mazzon, Sabina Cauci, Carlo Trombetta, Giuseppe Toffoli

androgen receptor CAG polymorphism GGN polymorphism androgenetic alopecia post-finasteride syndrome finasteride AR gene AGA PFS

Studysummary This study found that the less common CAG-rs4045402 and GGN-rs3138869 polymorphisms were more frequent in patients with post-finasteride syndrome and androgenetic alopecia, suggesting a genetic predisposition to AGA development.

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This study investigated the relationship between two genetic polymorphisms in the androgen receptor (AR) gene and the development of androgenetic alopecia (AGA) and post-finasteride syndrome (PFS). The study found that the longer CAG and GGN repeats were associated with a higher risk of AGA, and that the extreme values of both polymorphisms were associated with a reduced AR functionality. However, the study did not find a significant association between the two genetic polymorphisms and the occurrence of AGA or PFS. The study suggests that further prospective trials are needed to better investigate this phenomenon and to highlight possible pharmacogenetic predictive markers of toxicity development.

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research Genetic Variation in the Human Androgen Receptor Gene Is the Major Determinant of Common Early-Onset Androgenetic Alopecia

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