Effectiveness of Finasteride on Patients with Male Pattern Baldness Who Have Different Androgen Receptor Gene Polymorphism

    November 2005 in “ Journal of Investigative Dermatology Symposium Proceedings ”
    Nagaoki Wakisaka, Yuh-ichi Taira, Masahiro Ishikawa, Yoshio Nakamizo, Kazuhiro Kobayashi, Masashi Uwabu, Yasutaka Fukuda, Yasuyuki Taguchi, Takanori Hama, Masaya Kawakami
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    TLDR Finasteride works better for baldness in people with shorter gene repeats.
    This study analyzed the effectiveness of finasteride on male pattern baldness (MPB) patients with different androgen receptor (AR) gene polymorphism. The study found that the smaller the repeat number of the triplet repeats (CAG+ GGC) in the AR gene, the higher the improvement with finasteride. Patients with shorter repeat regions in the AR gene responded better to the drug than those with longer repeat regions, although the former patients tended to reveal severe initial symptoms. The determination of such polymorphism is thought to be useful in the drug choice for MPB patients.
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      in Research/Science  19 upvotes 2 months ago
      Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

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      in Treatment  7 upvotes 6 days ago
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      in Satire  233 upvotes 4 months ago
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      Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

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