Effectiveness of Finasteride on Patients with Male Pattern Baldness Who Have Different Androgen Receptor Gene Polymorphism

December 2005 in “ Journal of Investigative Dermatology Symposium Proceedings ”

Nagaoki Wakisaka, Yuh-ichi Taira, Masahiro Ishikawa, Yoshio Nakamizo, Kazuhiro Kobayashi, Masashi Uwabu, Yasutaka Fukuda, Yasuyuki Taguchi, Takanori Hama, Masaya Kawakami

finasteride male pattern baldness androgen receptor gene polymorphism CAG repeat GGC repeat androgen receptor gene AR gene Propecia MPB

TLDR Finasteride works better for baldness in people with shorter gene repeats.

This study analyzed the effectiveness of finasteride on male pattern baldness (MPB) patients with different androgen receptor (AR) gene polymorphism. The study found that the smaller the repeat number of the triplet repeats (CAG+ GGC) in the AR gene, the higher the improvement with finasteride. Patients with shorter repeat regions in the AR gene responded better to the drug than those with longer repeat regions, although the former patients tended to reveal severe initial symptoms. The determination of such polymorphism is thought to be useful in the drug choice for MPB patients.

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Research cited in this study

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The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

research The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

49 citations, August 2003 in “Journal of The American Academy of Dermatology”

Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

research Androgen Receptor Polymorphisms (CAG Repeat Lengths) in Androgenetic Alopecia, Hirsutism, and Acne

186 citations, July 1998 in “Journal of Cutaneous Medicine and Surgery”

Shorter CAG repeats may cause hair and skin issues, while longer ones may link to acne.

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community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community A Different Take on Curing MBP

16 upvotes 5 years ago

Addressing hair loss by focusing on posture, blood flow, and craniofacial development. Methods include improving posture, cardiovascular activity, scalp massages, healthy diet, meditation, using minoxidil, and addressing craniofacial issues.

community Finasteride doesn't work for me in 2 years and my bloodtest result just came in.

in Progress Pictures 88 upvotes 1 year ago

A user has been treating hair loss with finasteride for two years without success and is experiencing an itchy scalp with seborrhea. Despite low DHT levels, they are still losing hair, suggesting that DHT might not be the main cause of their hair loss, and they are considering other treatments or causes.

community Female, 30, PCOS diagnosis, MPB Norwood 2. Endo refuses to give anything other than Spironolactone. Feel like I’m at my wit’s end here.

in Female 53 upvotes 1 year ago

A 30-year-old female with PCOS and male pattern baldness is frustrated with her endocrinologist's recommendation of only Spironolactone and minoxidil, feeling that dutasteride, finasteride, and progesterone would be more effective. Other users suggest various online sources for treatments, warn against self-medicating due to potential risks, and recommend seeking a specialized endocrinologist or considering additional treatments like Inositol, Berberine, and dermaneedling.

community So we have 20k dollars human like machines available but no new effective treatment for hairloss since finasteride :)

in Chat 237 upvotes 2 months ago

There have been no new effective hair loss treatments since finasteride, despite technological advancements. Current treatments include finasteride, minoxidil, and RU58841, with ongoing challenges and potential future solutions in research.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 160 upvotes 1 year ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

Related Research

1 / 1 results

research Effectiveness of Finasteride on Patients with Male Pattern Baldness Who Have Different Androgen Receptor Gene Polymorphism

23 citations, December 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Finasteride works better for baldness in people with shorter gene repeats.