The Expression of Insulin-Like Growth Factor 1 in Follicular Dermal Papillae Correlates with Therapeutic Efficacy of Finasteride in Androgenetic Alopecia

August 2003 in “ Journal of The American Academy of Dermatology ”

Liren Tang, Olga Bernardo, Chantal Bolduc, Harvey Lui, Shabnam Madani, Jerry Shapiro

insulin-like growth factor 1 IGF-1 follicular dermal papillae finasteride androgenetic alopecia Propecia

TLDR Higher IGF-1 levels in hair follicles link to better finasteride results for hair loss.

This study from 19 years ago investigated the correlation between the expression of insulin-like growth factor 1 (IGF-1) in follicular dermal papillae and the therapeutic efficacy of finasteride in androgenetic alopecia. The study found that the expression of IGF-1 in follicular dermal papillae was significantly higher in responders to finasteride treatment compared to non-responders. This suggests that IGF-1 may play a role in the therapeutic efficacy of finasteride in androgenetic alopecia. However, further studies are needed to confirm these findings.

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Research cited in this study

10 / 10 results

research Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia

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28 citations, February 1999 in “Archives of Dermatological Research”

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19 citations, January 1997 in “Endocrinology”

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research Androgen Metabolism as It Affects Hair Growth in Androgenetic Alopecia

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research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations, July 1995 in “Biochemical and biophysical research communications”

Male hormones promote hair cell growth by using a growth factor from nearby skin cells.

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