5α-Reductase Inhibitors in Androgenetic Alopecia

September 2014 in “ Current Opinion in Endocrinology, Diabetes and Obesity ”

Elizabeth Yim, Katherine L. Baquerizo Nole, Antonella Tosti

5α-reductase inhibitors androgenetic alopecia finasteride dutasteride female pattern hair loss persistent diminished libido erectile dysfunction depression gynecomastia male breast cancer 5ARIs AGA Propecia Avodart FPHL

From the encyclopedia

Finasteride →

Frontline, gold standard treatment for combatting androgenic alopecia

Dutasteride →

Heavy duty finasteride that comes with higher risks

Studysummary This review discusses the efficacy and safety of 5-alpha reductase inhibitors for treating androgenetic alopecia, noting concerns about sexual side effects, which are typically uncommon and often resolve over time.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

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A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

research A Randomized, Active- and Placebo-Controlled Study of the Efficacy and Safety of Different Doses of Dutasteride Versus Placebo and Finasteride in the Treatment of Male Subjects with Androgenetic Alopecia

97 citations , January 2014 in “Journal of The American Academy of Dermatology”

This study found that dutasteride increased hair growth and restoration in men with androgenetic alopecia more effectively than finasteride and was well tolerated over 24 weeks.

research Efficacy of Finasteride for Treating Patients with Androgenetic Alopecia Who Are Pileous in Other Areas: A Pilot Study in Japan

5 citations , January 2014 in “Indian Journal of Dermatology”

In this study, oral finasteride was more effective in treating androgenetic alopecia in Japanese patients who also had body hair.

research Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice

9 citations , October 2013 in “PLOS ONE”

This study suggests that dutasteride may be more beneficial than finasteride for therapeutic or preventive use.

The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

research The Efficacy and Safety of 5α-Reductase Inhibitors in Androgenetic Alopecia: A Network Meta-Analysis and Benefit–Risk Assessment of Finasteride and Dutasteride

66 citations , June 2013 in “Journal of Dermatological Treatment”

This study reported no significant difference in efficacy or sexual dysfunction risk between 5α-reductase inhibitors and placebo for androgenetic alopecia, suggesting that dutasteride 0.5 mg may be considered pending further research.

research Male Breast Cancer and 5α-Reductase Inhibitors Finasteride and Dutasteride

32 citations , May 2013 in “The Journal of Urology”

This study found no statistically significant association between the use of 5α-reductase inhibitors and male breast cancer incidence.

research Secondary Infertility Due to Use of Low-Dose Finasteride

15 citations , October 2012 in “International Urology and Nephrology”

This case report describes a 40-year-old man whose secondary infertility, observed after prolonged finasteride use for hair loss, resolved following discontinuation of the drug, resulting in a live birth.

research Pattern Hair Loss in Men: Diagnosis, Genetic Link, Clinical Features, and Treatments

58 citations , September 2012 in “Dermatologic Clinics”

This article reviews current knowledge on the causes, diagnosis, and medical treatments for androgenetic alopecia, particularly in men, and reports no new findings.

research Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects

134 citations , August 2012 in “The Journal of Clinical Psychiatry”

This study found that former finasteride users with persistent sexual side effects reported significantly higher rates of depressive symptoms and suicidal thoughts compared to controls.

research Combination Therapy With Finasteride and Low-Dose Dutasteride in the Treatment of Androgenetic Alopecia

17 citations , June 2012 in “Australasian Journal of Dermatology”

This study found that adding low-dose dutasteride to ongoing finasteride treatment significantly improved hair density in a patient with androgenetic alopecia.

A Randomized Double-Blind, Vehicle-Controlled Bilateral Comparison Study of the Efficacy and Safety of Finasteride 0.5% Solution in Combination with Intense Pulsed Light in the Treatment of Facial Hirsutism

research A Randomized Double-Blind, Vehicle-Controlled Bilateral Comparison Study of the Efficacy and Safety of Finasteride 0.5% Solution in Combination with Intense Pulsed Light in the Treatment of Facial Hirsutism

5 citations , June 2012 in “Journal of Cosmetic and Laser Therapy”

This study found that combining topical finasteride with IPL + RF hair removal significantly reduced unwanted facial hair in women after six months compared to placebo.

Mesotherapy Using Dutasteride-Containing Preparation in Treatment of Female Pattern Hair Loss: Photographic, Morphometric and Ultrastructural Evaluation

research Mesotherapy Using Dutasteride-Containing Preparation in Treatment of Female Pattern Hair Loss: Photographic, Morphometric and Ultrastructural Evaluation

41 citations , April 2012 in “Journal of The European Academy of Dermatology and Venereology”

This study found that mesotherapy with a dutasteride-containing preparation improved hair growth indicators in female pattern hair loss better than saline, with minimal side effects and greater effectiveness in patients with shorter disease duration.

research Global Photographic Assessment of Men Aged 18 to 60 Years with Male Pattern Hair Loss Receiving Finasteride 1 mg or Placebo

35 citations , February 2012 in “Journal of The American Academy of Dermatology”

This study found that finasteride (1 mg) significantly increased hair growth in all scalp regions affected by male pattern hair loss over 24 months in men aged 18 to 60, with more pronounced effects in younger men.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , December 2011 in “Advances in Urology”

This review discusses the biochemical properties and clinical significance of 5 alpha-reductase isozymes and reports no new clinical results.

research Finasteride, 1 Mg Daily Administration on Male Androgenetic Alopecia in Different Age Groups: 10-Year Follow-Up

44 citations , July 2011 in “Dermatologic Therapy”

This study found that finasteride 1 mg was effective in improving androgenetic alopecia over 10 years in men, particularly those older than 30, with some reporting beneficial results even after 5 years.

research Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA

10 citations , May 2011

This pilot study found that a novel regimen including NuH Hair led to significant hair growth in male patients with androgenic alopecia, regardless of atopy status, with quicker results when additional treatment components were used.

research Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss

185 citations , March 2011 in “The Journal of Sexual Medicine”

This study found that 94% of healthy men reported low libido and 92% reported erectile dysfunction as persistent sexual side effects after using finasteride for male pattern hair loss, with these effects lasting on average 40 months post-discontinuation.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.

research Oral Finasteride Improved the Quality of Life of Androgenetic Alopecia Patients

23 citations , December 2010 in “Journal of Dermatology”

In this study, oral finasteride improved the quality of life for male patients with androgenetic alopecia, but it did not significantly reduce anxiety or correlate with reported anxiety levels.

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

152 citations , October 2010 in “Archives of Dermatology”

This study found that daily oral finasteride may increase hair count and improve hair appearance assessments in men with androgenetic alopecia, but it also appears to raise the risk of sexual dysfunction.

research S1 Guideline for Diagnostic Evaluation in Androgenetic Alopecia in Men, Women, and Adolescents

151 citations , August 2010 in “British Journal of Dermatology”

This guideline reviews the diagnosis of androgenetic alopecia and offers expert consensus recommendations tailored to males, females, and adolescents, but reports no new clinical results.

research 5 mg/Day Finasteride Treatment for Normoandrogenic Asian Women with Female Pattern Hair Loss

64 citations , June 2010 in “Journal of The European Academy of Dermatology and Venereology”

This study suggests that 5 mg/day oral finasteride may increase hair density and thickness in normoandrogenic Asian women with female pattern hair loss over 12 months.

Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

research Efficacy, Safety, and Tolerability of Dutasteride 0.5 mg Once Daily in Male Patients with Male Pattern Hair Loss: A Randomized, Double-Blind, Placebo-Controlled, Phase III Study

92 citations , June 2010 in “Journal of The American Academy of Dermatology”

This study found that 0.5 mg of dutasteride significantly improved hair growth compared to placebo and was well tolerated over six months in men with male pattern hair loss.

research Alopecia Secondary to Mesotherapy

49 citations , July 2009 in “Journal of the American Academy of Dermatology”

This report highlights two cases where patchy alopecia developed after mesotherapy for androgenetic alopecia, indicating potential risks associated with this treatment.

research Finasteride-Induced Gynecomastia: Case Reports and Review

8 citations , January 2009 in “Indian Journal of Dermatology, Venereology and Leprology”

Finasteride can cause rare breast growth side effect, with varying recovery after stopping.

research Comparing the Therapeutic Effects of Finasteride Gel and Tablet in Treatment of Androgenetic Alopecia

57 citations , January 2009 in “Indian Journal of Dermatology, Venereology and Leprology”

This study found that both topical and oral finasteride had similar therapeutic effects in treating male androgenic alopecia, with no significant differences in hair thickness, counts, or bald area size.

research Finasteride Induced Gynecomastia: Case Report and Review of the Literature

29 citations , January 2009 in “International Journal of Trichology”

This report describes two cases of gynecomastia linked to the use of Finasteride (Propecia®) for treating androgenetic alopecia, highlighting a rare but important side effect.

The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

research The Importance of Dual 5α-Reductase Inhibition in the Treatment of Male Pattern Hair Loss: Results of a Randomized Placebo-Controlled Study of Dutasteride Versus Finasteride

215 citations , November 2006 in “Journal of The American Academy of Dermatology”

This study found that dutasteride increased scalp hair growth in men with male pattern hair loss, particularly at a 2.5 mg dose, and was more effective than finasteride over 24 weeks.

research Changes in Hair Weight in Men with Androgenetic Alopecia After Treatment with Finasteride (1 mg Daily): Three- and Four-Year Results

66 citations , June 2006 in “Journal of The American Academy of Dermatology”

This study found that long-term finasteride treatment in men with androgenetic alopecia significantly increased hair weight and count compared to placebo over nearly four years.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations , May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.

research An Open, Randomized, Comparative Study of Oral Finasteride and 5% Topical Minoxidil in Male Androgenetic Alopecia

71 citations , January 2004 in “Dermatology”

This study found that oral finasteride was more effective than 5% topical minoxidil in treating mild to severe androgenetic alopecia in males, with both treatments deemed effective and safe over 12 months.

research Finasteride-Associated Male Infertility

34 citations , January 2004 in “Revista do Hospital das Clínicas”

The authors reported that young men with infertility-related conditions experienced improved seminal quality after stopping finasteride, suggesting potential adverse effects on fertility during treatment.

research Finasteride Treatment May Not Prevent Telogen Effluvium After Minoxidil Withdrawal

14 citations , September 2003 in “Archives of Dermatology”

This abstract provides no new data or findings as it is a placeholder text rather than a research summary.

research Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia

40 citations , September 2003 in “Archives of Dermatology”

This webpage provides access options for JAMA Dermatology but does not contain research findings or results.

research Depression Related to Finasteride Administration for Androgenetic Alopecia

88 citations , October 2002 in “Journal of Dermatology”

In this study, 19 patients treated with finasteride for androgenetic alopecia developed moderate to severe depression, which resolved after stopping the medication, suggesting an association between finasteride and mood disturbances.

research Comparative Efficacy of Various Treatment Regimens for Androgenetic Alopecia in Men

80 citations , August 2002 in “Journal of Dermatology”

This study found that combining oral finasteride with topical minoxidil resulted in the greatest improvement in hair growth for male patients with androgenetic alopecia, compared to using any single treatment.

research Finasteride Increases Anagen Hair in Men with Androgenetic Alopecia

129 citations , October 2000 in “British Journal of Dermatology”

This study found that finasteride increases anagen hair growth in men with androgenetic alopecia.

research New Topical Antiandrogenic Formulations Can Stimulate Hair Growth in Human Bald Scalp Grafted Onto Mice

37 citations , January 2000 in “International Journal of Pharmaceutics”

In a study using human scalp skin grafts on SCID mice, topical flutamide and finasteride significantly improved hair growth in male-pattern baldness compared to placebo, with flutamide showing superior results to finasteride.

research Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course

30 citations , January 1997 in “Journal of Dermatological Treatment”

This study reported that a 0.005% finasteride solution may encourage hair regrowth and reduce balding areas in patients with androgenic alopecia, without significant absorption or adverse effects.

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

This study found that topical finasteride and flutamide both significantly reduced sebaceous gland growth and decreased prostatic weights in hamsters, indicating systemic effects despite local application.

research Finasteride: The First 5 Alpha-Reductase Inhibitor

34 citations , July 1993 in “PubMed”

This article reviews the characteristics and uses of finasteride for benign prostatic hyperplasia, noting variable symptom improvement and ongoing investigation in other DHT-mediated conditions, and reports no new clinical results.

research The Effect of Finasteride in Men with Benign Prostatic Hyperplasia

1040 citations , October 1992 in “The New England Journal of Medicine”

In this study, 5 mg of finasteride per day significantly improved urinary symptoms and reduced prostate volume in men with benign prostatic hyperplasia, but increased the risk of sexual dysfunction.