Secondary Infertility Due to Use of Low-Dose Finasteride

This case report describes a 40-year-old man who experienced secondary infertility after prolonged use of low-dose finasteride for androgenetic alopecia. The patient had been using the drug for 8.5 years and had impaired semen parameters and sperm DNA damage. However, after discontinuing the drug, his semen parameters and sperm DNA fragmentation index improved, and his wife became pregnant and gave birth to a healthy baby boy. The study suggests that low-dose finasteride may cause spermatogenic failure and DNA damage, but discontinuing the drug can lead to improvement in semen quality and pregnancy.