Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study

    January 2007 in “ Archives of Andrology ”
    Giulia Collodel, G. Scapigliati, Elena Moretti
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    TLDR Finasteride may negatively affect male fertility.
    This study investigated the effects of chronic treatment with finasteride on sperm quality in three men. The study found that the drug caused a total absence of sperm in one patient, and severely reduced rapid and slow progressive motility in the other two patients. Sperm ultrastructure analysis showed high necrosis, and FISH sperm analysis showed elevated frequencies of aneuploidy. After cessation of finasteride, one patient showed recovery of spermatogenesis, but sperm pathologies were still higher than controls. The study suggests that chronic treatment with finasteride may have negative effects on male fertility.
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      community Had a son while being on FIN, MUST READ

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      A user shared his experience of having two healthy children while continuously using finasteride (Fin) for hair loss, challenging fears about its potential impact on fetal development. The discussion that followed included various perspectives, with some users sharing similar experiences, others expressing concerns about potential risks, and some emphasizing the need for more substantial evidence before drawing conclusions.

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