TLDR Finasteride may negatively affect male fertility.
This study investigated the effects of chronic treatment with finasteride on sperm quality in three men. The study found that the drug caused a total absence of sperm in one patient, and severely reduced rapid and slow progressive motility in the other two patients. Sperm ultrastructure analysis showed high necrosis, and FISH sperm analysis showed elevated frequencies of aneuploidy. After cessation of finasteride, one patient showed recovery of spermatogenesis, but sperm pathologies were still higher than controls. The study suggests that chronic treatment with finasteride may have negative effects on male fertility.
34 citations,
January 2004 in “Revista do Hospital das Clínicas” Finasteride may worsen infertility in men with existing issues, but stopping it can improve sperm health.
2 citations,
October 2000 in “The Journal of Urology” Finasteride daily doesn't affect sperm production or semen in young men.
26 citations,
October 2014 in “Andrologia” Infertile men are more likely to produce sperm with abnormal chromosome numbers, which can affect pregnancy success and embryo health.
10 citations,
October 2020 in “Microscopy and Microanalysis” Resveratrol helps prevent finasteride-induced damage in male rats, improving reproductive function.
13 citations,
June 2018 in “Current Urology Reports” Hair loss drugs may cause sexual issues and infertility in men.
127 citations,
June 2008 in “British Journal of Clinical Pharmacology” Low doses of some substances can be beneficial, while high doses can be harmful or toxic.
28 citations,
November 2003 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” The normal human prostate does not significantly affect blood DHT levels.
