Resveratrol Ameliorates the Seminiferous Tubules Damages Induced by Finasteride in Adult Male Rats

October 2020 in “ Microscopy and Microanalysis ”

Amany Mohamed Shalaby, Mohamed Ali Alabiad, Dina Fouad El Shaer

resveratrol seminiferous tubules finasteride testosterone dihydrotestosterone malondialdehyde histopathological alterations testes Propecia DHT

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Studysummary This study found that resveratrol significantly alleviated testicular damage in male rats caused by finasteride, which otherwise led to decreased testosterone levels and various histopathological alterations in the testes. Our plain-language summary of this paper — not a Tressless recommendation.

Resveratrol can protect the seminiferous tubules in male rats from damage caused by finasteride, which can lead to infertility. It was found to improve damages caused by finasteride in adult male rats, including a decrease in testosterone and dihydrotestosterone levels, an increase in malondialdehyde levels, and histopathological alterations in the testes. Resveratrol may help improve male reproductive function by reducing damage to the seminiferous tubules caused by finasteride in adult male rats.

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Research cited in this study

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research Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects

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research DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

research Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss

185 citations , March 2011 in “The Journal of Sexual Medicine”

This study found that 94% of healthy men reported low libido and 92% reported erectile dysfunction as persistent sexual side effects after using finasteride for male pattern hair loss, with these effects lasting on average 40 months post-discontinuation.

research Finasteride-Associated Male Infertility

38 citations , December 2010 in “Fertility and Sterility”

In this case report, a male patient's semen parameters improved after discontinuing a 1-mg dose of finasteride, suggesting that stopping the medication may benefit infertile men with previous sperm production issues.

research The Effect of Finasteride on Spermatogenesis of Mesocricetus Auratus

5 citations , June 2008 in “Acta Cirurgica Brasileira”

This study found that finasteride administration in hamsters led to significant spermatogenesis reduction and seminiferous tubule atrophy compared to the control group.

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations , February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

In this study, administering 5alpha-reductase inhibitors reduced dihydrotestosterone levels and was associated with mild, reversible decreases in semen parameters in healthy men.

research Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor

408 citations , May 2004 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism”

This study found that dutasteride more effectively reduced serum dihydrotestosterone levels than finasteride in patients with benign prostatic hyperplasia.

research Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats

18 citations , May 2002 in “BJUI”

This study found that chronic exposure to finasteride did not significantly impact spermatogenesis in rats.