Resveratrol Ameliorates the Seminiferous Tubules Damages Induced by Finasteride in Adult Male Rats

    October 2020 in “ Microscopy and Microanalysis ”
    Amany Mohamed Shalaby, Mohamed Ali Alabiad, Dina Fouad El Shaer
    Studysummary This study found that resveratrol significantly alleviated testicular damage in male rats caused by finasteride, which otherwise led to decreased testosterone levels and various histopathological alterations in the testes.
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    Research cited in this study 8

    1. Depressive Symptoms and Suicidal Thoughts Among Former Users of Finasteride With Persistent Sexual Side Effects The Journal of Clinical Psychiatry · 2012
    2. DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions Folia Histochemica et Cytobiologica · 2011
    3. Persistent Sexual Side Effects of Finasteride for Male Pattern Hair Loss The Journal of Sexual Medicine · 2011
    4. Finasteride-Associated Male Infertility Fertility and Sterility · 2010
    5. The Effect of Finasteride on Spermatogenesis of Mesocricetus Auratus Acta Cirurgica Brasileira · 2008
    6. The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men The Journal of Clinical Endocrinology and Metabolism · 2007
    7. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    8. Effects of the Chronic Use of Finasteride on Testicular Weight and Spermatogenesis in Wistar Rats BJUI · 2002