DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions

    April 2011 in “ Folia Histochemica et Cytobiologica ”
    Agnieszka Kolasa, Mariola Marchlewicz, L Wenda-Rózewicka, Barbara Wiszniewska
    Studysummary In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.
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    Research cited in this study 8

    1. DHT Deficiency Perturbs the Integrity of the Rat Seminiferous Epithelium by Disrupting Tight and Adherens Junctions Folia Histochemica et Cytobiologica · 2011
    2. The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency Cellular & Molecular Biology Letters · 2009
    3. Expression of E-SOD, GPX5 mRNAs and Immunoexpression of Cu/ZnSOD in Epididymal Epithelial Cells of Finasteride-Treated Rats Andrologia · 2008
    4. Actions of 5α-Reductase Inhibitors on the Epididymis Molecular and Cellular Endocrinology · 2006
    5. Epididymis in an Experimental Model of DHT Deficiency: Immunolocalization of ERalpha and ERbeta in Rat Epididymal Epithelial Cells. In Vivo and In Vitro Studies PubMed · 2006
    6. Immunolocalization of Androgen Receptor in the Epididymis of Rats with Dihydrotestosterone Deficiency PubMed · 2005
    7. Morphology of the Testis and the Epididymis in Rats with Dihydrotestosterone Deficiency PubMed · 2004
    8. Steroid 5α-Reductases and 3α-Hydroxysteroid Dehydrogenases: Key Enzymes in Androgen Metabolism Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism · 2001