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    Glossary Tight Junctions

    specialized cell connections that prevent molecule and ion passage

    Tight junctions, also known as occluding junctions or zonula occludens, are specialized connections between adjacent cells in epithelial and endothelial tissues. They create a seal that prevents the passage of molecules and ions through the space between cells, thereby maintaining the distinct environments on either side of the tissue layer. This is crucial for functions such as maintaining the blood-brain barrier and regulating the absorption of nutrients in the intestines.

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    1. The role of tight junctions in skin barrier function and dermal absorption Journal of controlled release · 2016 · 156 citations
    2. DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions Folia Histochemica et Cytobiologica · 2011 · 27 citations
    3. Tight junctions form a barrier in porcine hair follicles European journal of cell biology · 2015 · 21 citations
    4. Testosterone Reduces Tight Junction Complexity and Down-regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-steroid Replacement Rats in Vivo · 2019 · 10 citations
    5. Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis Journal of Dermatological Science · 2016 · 1 citations
    6. LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy Journal of Investigative Dermatology · 2019
    7. Tight Junction barriers in human hair follicles – role of claudin-1 Scientific reports · 2018 · 39 citations
    8. Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity Cell reports · 2018 · 25 citations
    9. The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions International Journal of Molecular Sciences · 2022 · 11 citations
    10. Drug delivery to the hair follicle : role of follicular tight junctions as a biological barrier and the potential for targeting clobetasol nanocarriers SciDok (Saarland University and State Library) · 2015
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