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Glossary Tight Junctions

specialized cell connections that prevent molecule and ion passage

Tight junctions, also known as occluding junctions or zonula occludens, are specialized connections between adjacent cells in epithelial and endothelial tissues. They create a seal that prevents the passage of molecules and ions through the space between cells, thereby maintaining the distinct environments on either side of the tissue layer. This is crucial for functions such as maintaining the blood-brain barrier and regulating the absorption of nutrients in the intestines.

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research The role of tight junctions in skin barrier function and dermal absorption

156 citations , August 2016 in “Journal of controlled release”

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

research Tight Junction barriers in human hair follicles – role of claudin-1

39 citations , August 2018 in “Scientific reports”

This study demonstrated that tight junction barriers exist in human hair follicles but are less tight in hair follicle keratinocytes than in interfollicular keratinocytes, highlighting claudin-1's key role in follicle barrier function and growth.

research DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

research Tight junctions form a barrier in porcine hair follicles

21 citations , December 2015 in “European journal of cell biology”

In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.

Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats

research Testosterone Reduces Tight Junction Complexity and Down-regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-steroid Replacement Rats

10 citations , December 2019 in “in Vivo”

This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.

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community Libido on Finasteride

4 upvotes 11 years ago

The conversation discusses the effects of finasteride on libido, with the original poster experiencing a significant decrease in sexual desire after starting the medication. Other users share similar experiences and suggest potential remedies, including Vitamin E supplementation and lifestyle changes like avoiding pornography.

community Just started dut and I’m curious to hear yalls experiences with it.

in Finasteride/Dutasteride 17 upvotes 1 year ago

Dutasteride is considered a stronger alternative to finasteride for hair loss, with mixed results; some users report improvement, while others experience worsening or side effects. Effectiveness varies, with genetics and individual responses influencing outcomes.

community 2+ Years of Finasteride treatment - Stopped hair-loss, got regrowth, but

24 upvotes 1 year ago

The user experienced successful hair regrowth with Finasteride and Minoxidil but developed erectile dysfunction and abdominal pain, possibly due to medication or lifestyle changes. They plan to consult a urologist and consider adjusting medication or trying supplements like zinc, DIM, or boron.

community hairloss in my 20s has ruined my life.

in Research/Science 373 upvotes 1 year ago

A person in their 20s is struggling with hair loss, using treatments like minoxidil and finasteride. Suggestions include self-improvement, therapy, hair transplants, and focusing on acceptance and confidence.

community If RU58841 is such an effective anti androgen

in Research/Science 46 upvotes 2 years ago

RU58841 is discussed as a topical anti-androgen for hair loss, but its effectiveness and safety are not well-documented, leading to mixed opinions and experiences among users. Some combine it with finasteride, but concerns about side effects and lack of FDA approval limit its popularity.

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High & Tight SMP- Scalp MicropigmentationCharleston, SC · US

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