Search

for
Search:

Glossary Tight Junctions

specialized cell connections that prevent molecule and ion passage

Tight junctions, also known as occluding junctions or zonula occludens, are specialized connections between adjacent cells in epithelial and endothelial tissues. They create a seal that prevents the passage of molecules and ions through the space between cells, thereby maintaining the distinct environments on either side of the tissue layer. This is crucial for functions such as maintaining the blood-brain barrier and regulating the absorption of nutrients in the intestines.

Related Terms

Sort by

Research

30 / 1000+ results

research The role of tight junctions in skin barrier function and dermal absorption

156 citations , August 2016 in “Journal of controlled release”

This review summarizes current knowledge on tight junctions in mammalian skin and their role in drug delivery and interaction with other barrier components, but reports no new experimental results.

research Tight Junction barriers in human hair follicles – role of claudin-1

39 citations , August 2018 in “Scientific reports”

This study demonstrated that tight junction barriers exist in human hair follicles but are less tight in hair follicle keratinocytes than in interfollicular keratinocytes, highlighting claudin-1's key role in follicle barrier function and growth.

research DHT deficiency perturbs the integrity of the rat seminiferous epithelium by disrupting tight and adherens junctions

27 citations , April 2011 in “Folia Histochemica et Cytobiologica”

In this study using rats, finasteride-induced DHT deficiency led to morphological changes in seminiferous tubules, linked with altered junctional protein expression, potentially impairing fertility.

research Tight junctions form a barrier in porcine hair follicles

21 citations , December 2015 in “European journal of cell biology”

In this study, researchers demonstrated that follicular tight junctions in porcine skin form a barrier to nanoparticle penetration, particularly in upper regions, which supports its use as a model for human skin.

Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats

research Testosterone Reduces Tight Junction Complexity and Down-regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-steroid Replacement Rats

10 citations , December 2019 in “in Vivo”

This study found that administering testosterone to ovariectomized female rats decreased endometrial tight junction complexity and expression of specific proteins, potentially affecting embryo implantation.

research Epidermis-specific ablation of claudin-1 in adult mice demonstrates the essential role of a tight junction barrier in skin homeostasis

1 citations , September 2016 in “Journal of Dermatological Science”

In this study using tamoxifen-inducible claudin-1 knockout mice, researchers observed that tight junction barrier leakage induced stratum corneum barrier defects and skin inflammation, suggesting a possible cycle of barrier damage and inflammation in atopic dermatitis.

Three-Dimensional Imaging of Tight Junction Network Across Multiple Layers of Human Epidermis by Array Tomography Using Backscattered Electron-Mode Scanning Electron Microscopy

research LB1081 Three-dimensional imaging of tight junction-network across multiple layers of human epidermis by array tomography using backscattered electron-mode scanning electron microscopy

August 2019 in “Journal of Investigative Dermatology”

This study found that tight junctions extend to the most superficial layer of the stratum granulosum in human skin, challenging previous claims of their limited presence in the epidermis.

research Esrp1-Regulated Splicing of Arhgef11 Isoforms Is Required for Epithelial Tight Junction Integrity

25 citations , November 2018 in “Cell reports”

This study found that the ablation of Esrp1 and Esrp2 disrupts epithelial tight junctions by affecting Arhgef11 isoform expressions, highlighting a potential mechanistic link between splicing alterations and epithelial barrier defects.

research The Fate of Epidermal Tight Junctions in the stratum corneum: Their Involvement in the Regulation of Desquamation and Phenotypic Expression of Certain Skin Conditions

11 citations , July 2022 in “International Journal of Molecular Sciences”

This study found that treating reconstructed human epidermis with beta-lipohydroxy salicylic acid increased tight junction remnants in the stratum corneum, potentially affecting skin cohesion and desquamation.

research Drug delivery to the hair follicle : role of follicular tight junctions as a biological barrier and the potential for targeting clobetasol nanocarriers

January 2015 in “SciDok (Saarland University and State Library)”

This study confirmed the porcine ear skin model's effectiveness for studying nanoparticle-based drug delivery in human hair follicles, noting particle-dependent uptake and enhancement by massage.

research Transcriptome Profiling of Pilosebaceous Units in Male Androgenetic Alopecia Reveals Altered Junctional Networks

February 2021 in “Journal of Investigative Dermatology”

This study found that specific junctional proteins are significantly downregulated in balding regions of the scalp in men with androgenetic alopecia, suggesting disrupted cell communication may play a role in hair loss.

research Epithelial Integrity Is Maintained by a Matriptase-Dependent Proteolytic Pathway

137 citations , October 2009 in “The American journal of pathology”

This study found that matriptase, a membrane serine protease, is crucial for maintaining multiple types of epithelial tissues in mice, with its absence leading to severe organ dysfunction and increased permeability.

research Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis

47 citations , September 2012 in “Human molecular genetics online/Human molecular genetics”

This study suggests that the interaction between folliculin and plakophilin-4 (p0071) may play a role in folliculin's tumor suppressor function by regulating RhoA signaling, impacting cell migration and junction formation.

Essential Role of Polarity Protein Par3 for Epidermal Homeostasis Through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

research Essential Role of Polarity Protein Par3 for Epidermal Homeostasis through Regulation of Barrier Function, Keratinocyte Differentiation, and Stem Cell Maintenance

26 citations , July 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, loss of epidermal Par3 in mice disrupted the skin barrier and affected cell differentiation and stem cell maintenance, highlighting its role in epidermal homeostasis.

research Fine Structure of the Fully Keratinized Hair Cuticle in the Head Hair of the Human

11 citations , January 1981 in “Cells Tissues Organs”

This article describes the structure and components of hair cuticle cells and their intercellular junctions but reports no new clinical results.

research Claudin Expression Modulations Reflect an Injury Response in the Murine Epidermis

9 citations , July 2007 in “Journal of Investigative Dermatology”

This study found that exposure to 12-O-tetradecanoyl-phorbol-13-acetate in mouse skin caused changes in claudin expression and localization, indicating disruption and eventual recovery of the epidermal barrier.

research Understanding the Characteristics of the Scalp for Developing Scalp Care Products

7 citations , January 2021 in “Journal of Cosmetics Dermatological Sciences and Applications”

This review discusses the characteristics and interactions of the scalp barrier, dandruff, and scalp sensitivity but reports no new clinical results.

research Formation of the cornified envelope

3 citations , September 2005 in “Experimental dermatology”

This review discusses the formation and structure of the cornified cell envelope in the epidermis, highlighting biochemical pathways and genetic factors, but presents no new experimental results.

Serenoa Repens and N-Acetyl Glucosamine/Milk Proteins Complex Differentially Affect the Paracrine Communication Between Endothelial and Follicle Dermal Papilla Cells

research Serenoa repens and N‐acetyl glucosamine/milk proteins complex differentially affect the paracrine communication between endothelial and follicle dermal papilla cells

3 citations , November 2018 in “Journal of cellular physiology”

In laboratory settings, this study suggests that Serenoa repens and N-acetyl glucosamine with milk proteins may promote hair follicle vascularization through specific cellular interactions and actions.

Transcriptome Analysis Reveals the Genetic Basis Underlying the Development of Skin Appendages and Immunity in Hedgehog (Atelerix Albiventris)

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

2 citations , August 2020 in “Scientific reports”

This study identified genes potentially involved in the development and differentiation of skin appendages in Atelerix albiventris, noting significant enrichment of immune-related genes in hair-type tissues.

research The Role of Paracellular Transport in the Intestinal Absorption and Biopharmaceutical Characterization of Minoxidil

1 citations , June 2022 in “Pharmaceutics”

This study found that paracellular transport significantly contributes to the intestinal permeability of minoxidil, suggesting its limited suitability as a Biopharmaceutics Classification System reference drug due to potential variability.

Lactiplantibacillus Plantarum Lysate From Green Tea Leaves Alleviates Effects of Malassezia Restricta on Human Scalp Cells

research Lactiplantibacillus plantarum lysate isolated from green tea leaves alleviates the effects of Malassezia restricta on primary human scalp cells

March 2025 in “Research Square (Research Square)”

This study explored the potential of the lysate and lipoteichoic acid from Lactiplantibacillus plantarum APsulloc 331261 to improve scalp seborrheic dermatitis by modulating inflammatory and lipogenesis pathways in vitro, suggesting potential as a natural treatment option.

research Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

May 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

This study found that hair-type tissues in hedgehogs show higher enrichment of immune-related genes compared to spine-type tissues, suggesting that spines evolved to protect against injuries and infections.

research Identification and characterization of circRNAs in the skin during the wool follicle development of Aohan fine wool sheep

October 2019 in “Research Square (Research Square)”

In this study, researchers identified and analyzed 8,753 circular RNAs in Aohan fine wool sheep, suggesting that certain circRNAs may play a crucial role in regulating wool follicle growth.

research Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway

January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology”

This study found that minoxidil increases trabecular meshwork cell permeability, possibly via the downregulation of tight junction proteins and the generation of reactive oxygen species.

Examining Mammary Gland Transcriptomic Profiles Using RNA-Seq in Slick and Wild-Type Haired Holstein Cattle Under Tropical Conditions

research PSXIV-17 Examining Mammary Gland Transcriptomic Profiles Using Rna-Seq in Slick and Wild-Type Haired Holstein Cattle Under Tropical Conditions

November 2023 in “Journal of animal science/Journal of animal science ... and ASAS reference compendium”

This study investigated differences in gene expression in the mammary glands of SLICK and wild-type Holstein cattle, finding limited differences overall but identifying enriched pathways related to arachidonic acid metabolism and oxytocin production, which merit further exploration.

research 519 The role of the leaky gut in the development of alopecia areata

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study found that inducing a leaky gut in mice led to increased gut permeability and decreased expression of protective genes, suggesting a potential link to alopecia areata.

research 647 Alternative splicing factor Esrp1 controls homeostasis of skins by regulating barrier formation and function

April 2018 in “The journal of investigative dermatology/Journal of investigative dermatology”

This commentary discusses the crucial role of the alternative splicing factor Esrp1 in maintaining skin barrier function and its association with skin diseases like atopic dermatitis and psoriasis, but reports no new clinical results.

research The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis

January 2014 in “eScholarship (California Digital Library)”

In this study, researchers observed that TLR3 and scavenger receptors play key roles in skin barrier repair following UVB damage, contributing to our understanding of cellular responses to skin injury.

research The risk of hydroquinone and sunscreen over-absorption via photodamaged skin is not greater in senescent skin as compared to young skin: Nude mouse as an animal model

18 citations , May 2014 in “International journal of pharmaceutics”

This study found that UVA and UVB exposure increased hydroquinone and sunscreen absorption in nude mouse skin, with less absorption enhancement observed in more lipophilic sunscreens.