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GlossaryOccludin

protein maintaining cell junction integrity in tissues

Occludin is a protein that plays a crucial role in maintaining the integrity of tight junctions, which are structures that seal the spaces between cells in tissues. These tight junctions are essential for controlling the movement of substances between cells, thereby maintaining the barrier function of epithelial and endothelial layers. In simpler terms, occludin helps keep cells tightly connected, ensuring that unwanted substances can't easily pass through the spaces between them.

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research Effect of Minoxidil on Trabecular Outflow via the Paracellular Pathway

January 2020 in “Korean journal of ophthalmology/Korean Journal of Ophthalmology”

Minoxidil increases cell layer permeability by reducing tight junction proteins and raising ROS levels.

research Ancient Lineages of the Keratin-Associated Protein (KRTAP) Genes and Their Co-Option in the Evolution of the Hair Follicle

2 citations, March 2023 in “BMC ecology and evolution”

Some hair protein genes evolved early and were adapted for use in hair follicles.

research Ancient Lineages of the Keratin-Associated Protein (KRTAP) Genes and Their Co-option in the Evolution of the Hair Follicle

November 2022 in “Research Square (Research Square)”

Keratin-associated proteins have ancient origins and were used for different purposes before being adapted for hair in mammals.

research The Role of the Leaky Gut in the Development of Alopecia Areata

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

A compromised gut may trigger the autoimmune hair loss condition Alopecia Areata.

Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats

research Testosterone Reduces Tight Junction Complexity and Down-Regulates Expression of Claudin-4 and Occludin in the Endometrium in Ovariectomized, Sex-Steroid Replacement Rats

10 citations, December 2019 in “in Vivo”

Testosterone makes the connections in the uterus lining simpler and lowers certain protein levels, which might lead to infertility.

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