Immunolocalization of Androgen Receptor in the Epididymis of Rats with Dihydrotestosterone Deficiency
November 2005
in “
PubMed
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary This study found that finasteride altered androgen receptor expression in the rat epididymis without affecting the morphology of epididymal epithelium, suggesting a change in hormonal status.
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The study investigated the effects of dihydrotestosterone (DHT) deficiency on androgen receptor (AR) localization in the epididymis of rats treated with finasteride for 56 days. Despite the DHT deficiency, there were no morphological changes in the epididymal epithelium. In control rats, AR was found in the nuclei of epithelial and smooth muscle cells and mainly in the cytoplasm of interstitial cells. In finasteride-treated rats, AR was primarily located in the cytoplasm of epithelial and interstitial cells, with some nuclear staining in specific cell types. The study concluded that finasteride altered AR expression in the rat epididymis, reflecting changes in hormonal status without affecting the tissue morphology.
