Effect of Testosterone, Dihydrotestosterone, Estradiol, and Cortisol on the Quality of Fresh and Cryopreserved Stallion Sperm

June 2022 in “ Journal of Experimental Biology and Agricultural Sciences ”

Anna M. Shitikova, Mikhail Atroshchenko, Lidia V. Krokhotina, Mariya Engalycheva, M.N. Dmitriyeva

testosterone dihydrotestosterone estradiol cortisol sperm motility sperm cryopreservation sperm survival rates ejaculate volume total sperm count steroid hormone concentrations DHT sperm freezing

TLDR Higher testosterone harms sperm motility, while higher estradiol improves sperm survival.

This study on 40 stallions of various breeds examined the impact of testosterone, dihydrotestosterone, estradiol, and cortisol on the quality of fresh and cryopreserved sperm. It found that higher testosterone levels negatively correlated with both total and progressive sperm motility in both fresh and cryopreserved samples. Conversely, higher estradiol levels positively correlated with sperm survival rates in both conditions. Dihydrotestosterone levels were positively associated with ejaculate volume and total sperm count. Cortisol levels showed no significant correlation with sperm quality. The findings suggest that steroid hormone concentrations should be considered when selecting stallions for sperm cryopreservation.

View this study on jebas.org →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

195 citations, February 2007 in “The Journal of Clinical Endocrinology and Metabolism”

Dutasteride and finasteride may reduce sperm count and volume but don't affect movement or shape; effects are reversible after stopping.

Similar Research

5 / 1000+ results

research New Biomarkers to Evaluate Hyperandrogenemic Women and Hypogonadal Men

14 citations, January 2018 in “Advances in Clinical Chemistry”

The document concludes that hormonal biomarkers are key for diagnosing hyperandrogenemia in women and hypogonadism in men.

research Spermatozoa and Chronic Treatment with Finasteride: A TEM and FISH Study

23 citations, January 2007 in “Archives of Andrology”

Finasteride may negatively affect male fertility.

research Finasteride: The First 5α-Reductase Inhibitor

23 citations, July 1993 in “Pharmacotherapy”

Finasteride treats enlarged prostate and baldness, but may cause limited urinary improvement and sex-related side effects.

research Prolonged Use of Finasteride-Induced Gonadal Sex Steroids Alterations, DNA Damage, and Menstrual Bleeding in Women

1 citations, January 2020 in “Bioscience Reports”

Long-term use of finasteride in women can cause hormonal changes, DNA damage, and menstrual issues.

research Androgen Antagonists in Androgen Target Tissues

27 citations, January 1984 in “Pharmacology & Therapeutics”

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

Effect of Testosterone, Dihydrotestosterone, Estradiol, and Cortisol on the Quality of Fresh and Cryopreserved Stallion Sperm

Research cited in this study

research The Effect of 5α-Reductase Inhibition with Dutasteride and Finasteride on Semen Parameters and Serum Hormones in Healthy Men

Related Community Posts Join

community My hair after 3 steroid cycles

community Please take a vitamin & hormone test

community Spironolactone for 11 years, finasteride for almost 5 years, started oral minoxidil in November 😢 ended oral contraceptive in Dec.

community Be careful when switching from Finasteride to Dutasteride because for more efficacy.

community 5 months of nuking T, 2 months of minoxidil