Morphology of the Testis and the Epididymis in Rats with Dihydrotestosterone Deficiency
January 2004
in “
PubMed
”
New to Finasteride? There is a guide in the encyclopedia. Read the guide → Studysummary In this study, finasteride treatment for 56 days in adult rats led to sloughing of immature germinal cells and reduced sperm content in the epididymis, indicating its importance for maintaining spermatogenesis.
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The study investigated the effects of dihydrotestosterone (DHT) deficiency on the morphology of the testis and epididymis in adult rats treated with finasteride for 28 and 56 days. After 28 days, there was no significant impact on the seminiferous epithelium structure. However, after 56 days, finasteride treatment led to the sloughing of immature germinal cells into the seminiferous tubules and a reduced spermatozoa content in the epididymis. These findings suggested that 5alpha-reductase 2 activity was crucial for maintaining spermatogenesis, and the decreased spermatozoa content reflected the condition of the seminiferous epithelium.
