Morphology of the Testis and the Epididymis in Rats with Dihydrotestosterone Deficiency

January 2004 in “ PubMed ”

Agnieszka Kolasa, Mariola Marchlewicz, L Wenda-Rózewicka, Barbara Wiszniewska

dihydrotestosterone DHT finasteride 5alpha-reductase 2 spermatogenesis seminiferous epithelium epididymis Propecia

TLDR DHT deficiency in rats reduces sperm content and affects testis structure over time.

The study investigated the effects of dihydrotestosterone (DHT) deficiency on the testis and epididymis morphology in adult rats treated with finasteride. After 28 days of treatment, there was no significant impact on the seminiferous epithelium structure. However, after 56 days, finasteride treatment led to the sloughing of immature germinal cells into the seminiferous tubules and a reduced content of spermatozoa in the epididymis. These findings suggested that 5alpha-reductase 2 activity was crucial for maintaining spermatogenesis, and the observed decrease in spermatozoa content could indicate changes in the seminiferous epithelium condition.

View this study on pubmed.ncbi.nlm.nih.gov →

Discuss this study in the Community →

Research cited in this study

1 / 1 results

research Steroid 5α-Reductases and 3α-Hydroxysteroid Dehydrogenases: Key Enzymes in Androgen Metabolism

115 citations , March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Key enzymes control androgen levels, affecting hormone activity and potential treatments.

Related Community Posts Join

6 / 205 results

community The case for Dutasteride ONCE A WEEK vs daily Fin/Dut as cost effective light approach

in Finasteride/Dutasteride 12 upvotes 4 years ago

Dutasteride once a week may be a cost-effective alternative to daily finasteride for reducing DHT levels, with potential benefits for those seeking a lighter approach to hair loss treatment. Some users combine dutasteride with finasteride, minoxidil, and dermarolling for improved results.

community Can I still save my hairline at age of 15?

in General 476 upvotes 2 weeks ago

A 15-year-old is concerned about hair loss, possibly at Norwood 2 or 3, and is using shampoos and conditioners recommended by a trichologist. Suggestions include considering topical minoxidil and consulting a doctor about topical anti-DHT treatments like finasteride or RU58841, but avoiding 5-alpha-reductase inhibitors at this age.

community My Testosterone is less than 1/3rd In 7 Months since I took Finasteride!

in Finasteride/Dutasteride 112 upvotes 2 years ago

A user experienced a significant drop in testosterone levels after taking finasteride, leading to side effects like low libido and muscle mass loss. Despite its effectiveness for hair, the user decided to stop finasteride due to its impact on hormones, preferring to be bald.

community I have been on finasteride for 9 months. (6 months on 0.25 mg, 3 months into 0.5 mg daily) here are the progress pictures.

in Progress Pictures 273 upvotes 6 months ago

A user shared progress pictures after 9 months on finasteride, starting with 0.25 mg and increasing to 0.5 mg daily, noting improved hair density, especially at the crown, with initial side effects that resolved after the first month. The discussion includes user experiences with finasteride, concerns about side effects, and alternative treatments like rosemary oil and platelet-rich plasma therapy.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 year ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community DHT Itch is real. The connection between Acne and Male Pattern Baldness shows this

in Research/Science 64 upvotes 2 years ago

The conversation discusses the link between seborrheic dermatitis, acne, and male pattern baldness, suggesting that DHT may cause both skin conditions and hair loss. Treatments mentioned include RU58841, finasteride, dutasteride, minoxidil, Nizoral shampoo, and other topical anti-androgens.

Related Research

2 / 2 results

research Androgen Levels and Apoptosis in the Testis During Postnatal Development of Finasteride-Treated Male Rat Offspring

10 citations , September 2015 in “Folia Histochemica Et Cytobiologica”

Finasteride treatment in male rats can reduce fertility and affect sperm development in their offspring.

research Steroid 5α-Reductases and 3α-Hydroxysteroid Dehydrogenases: Key Enzymes in Androgen Metabolism

115 citations , March 2001 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

Key enzymes control androgen levels, affecting hormone activity and potential treatments.