The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency

    January 2009 in “ Cellular & Molecular Biology Letters ”
    Agnieszka Kolasa, Mariola Marchlewicz, Rafał Kurzawa, Wojciech Głąbowski, Grzegorz Trybek, L Wenda-Rózewicka, Barbara Wiszniewska
    TLDR DHT deficiency increases iNOS expression in rat testis and epididymis.
    The study examined the effects of dihydrotestosterone (DHT) deficiency, induced by finasteride, on inducible nitric oxide synthase (iNOS) expression in the testis and epididymis of 20 Wistar rats. Results showed that a 56-day finasteride treatment significantly decreased DHT levels and increased iNOS expression, particularly in the seminiferous and epididymal epithelium. This increase was observed in various cell types, including Sertoli cells, spermatids, and Leydig cells, suggesting that iNOS expression is regulated by DHT. The study concluded that DHT deficiency affects iNOS expression, potentially influencing the morphology and function of male reproductive tissues, and highlighted the complex regulation of iNOS by DHT, warranting further investigation.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 204 results

      community Fevipiprant 2019!

       18 upvotes 9 years ago
      The conversation discusses Fevipiprant, an asthma drug that may block CRTH2 and potentially stop male pattern baldness (MPB) without inhibiting DHT. It also mentions the use of finasteride and dutasteride for hair loss.

      community Why is dht bad for scalp hair but good for hair on the rest of body?

      in Satire  109 upvotes 2 years ago
      The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

      community Saying creatine causes loss on fin/dut makes no sense and this is why

      in Finasteride/Dutasteride  42 upvotes 1 year ago
      The conversation discusses whether creatine causes hair loss for those using finasteride or dutasteride, with some suggesting creatine might increase DHT or upregulate androgen receptors, potentially leading to hair loss. Others argue the evidence is not conclusive, citing limited studies and personal anecdotes, with some avoiding creatine as a precaution.

      community FINASTRIDE and switch to DUTASTRIDE, my experience

      in Progress Pictures  145 upvotes 1 year ago
      The user shared their experience with Finasteride and Dutasteride for hair loss. They initially had success with Finasteride but switched to Dutasteride after experiencing shedding, which continued, and are now considering a hair transplant.

    Related Research

    5 / 5 results