The Expression of Inducible Nitric Oxide Synthase (iNOS) in the Testis and Epididymis of Rats with a Dihydrotestosterone (DHT) Deficiency

    January 2009 in “ Cellular & Molecular Biology Letters ”
    Agnieszka Kolasa, Mariola Marchlewicz, Rafał Kurzawa, Wojciech Głąbowski, Grzegorz Trybek, L Wenda-Rózewicka, Barbara Wiszniewska
    TLDR DHT deficiency increases iNOS expression in rat testis and epididymis.
    The study examined the effects of dihydrotestosterone (DHT) deficiency, induced by finasteride, on inducible nitric oxide synthase (iNOS) expression in the testis and epididymis of 20 Wistar rats. Results showed that a 56-day finasteride treatment significantly decreased DHT levels and increased iNOS expression, particularly in the seminiferous and epididymal epithelium. This increase was observed in various cell types, including Sertoli cells, spermatids, and Leydig cells, suggesting that iNOS expression is regulated by DHT. The study concluded that DHT deficiency affects iNOS expression, potentially influencing the morphology and function of male reproductive tissues, and highlighted the complex regulation of iNOS by DHT, warranting further investigation.
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