TLDR Finasteride causes sperm production decrease in Mesocricetus auratus.
This study investigated the effect of finasteride on the spermatogenesis of adult Mesocricetus auratus. The experimental group was given finasteride for 90 days, and the results showed significant tubules atrophy and spermatogenesis reduction compared to the control group. The study highlights concerns about the use of finasteride in patients of fertile age due to its potential impact on androgen metabolism. Further investigation is needed to determine the safe dose of finasteride to be used and its administration interval.
Cited in this study
4 / 4 results
18 citations
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June 2002 in “BJUI” Finasteride doesn't change rat testicle weight or sperm production.
2 citations
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October 2000 in “The Journal of Urology” Finasteride daily doesn't affect sperm production or semen in young men.
1054 citations
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February 1998 in “The New England Journal of Medicine” Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.
211 citations
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November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively treats BPH, but needs more trials to understand potential.
August 2020 in “DOAJ (DOAJ: Directory of Open Access Journals)” Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.
5 citations
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May 2008 in “Acta Cirurgica Brasileira” Finasteride causes sperm production decrease in Mesocricetus auratus.
