The Effects of Finasteride on the Expression of Dazl, Tsga10, Sycp3, Prm2 Genes During Spermatogenesis in Testes of NMRI Mice

    August 2020 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    S Mohebali, N Hayati Roodbari, Reza Hajihosseini, Kazem Parivar
    TLDR Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.
    The study, conducted on male NMRI mice for 35 days, investigated the impact of Finasteride on the expression of four biomarkers of the spermatogenesis process: Dazl, Tsga10, Sycp3, and Prm2. The mice were divided into three groups, each receiving different doses of Finasteride (1, 5, and 20 mg/body weight). The results showed that at a dose of 20 mg/body weight, the expression levels of Dazl and Prm2 genes significantly decreased. At doses of 5 and 20 mg/body weight, the expression levels of Sycp3 and Tsga10 genes were significantly reduced. The study concluded that Finasteride, at a dose of 5 mg/body weight or higher, might have adverse effects on male spermatogenesis and fertility.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      Can’t tolerate fin, am I screwed?

      community Can’t tolerate fin, am I screwed?

      in Finasteride  114 upvotes 5 days ago
      The user experienced sexual side effects from a topical finasteride and minoxidil combo and stopped using it after three weeks. They plan to use foam minoxidil nightly to slow hair loss and seek alternative treatments that don't affect sexual health.

      community How to safely stop topical finasteride?

      in Finasteride  63 upvotes 6 days ago
      A user is concerned about running out of topical minoxidil and finasteride and seeks advice on safely transitioning to using minoxidil alone. They wish to avoid oral finasteride due to potential side effects and have a dermatologist appointment scheduled.

      community Is it normal that fin tingles in the mouth?

      in Finasteride  59 upvotes 1 week ago
      A user experienced a tingling sensation in their mouth after taking a cut finasteride pill, possibly due to inactive ingredients like mannitol or sodium lauryl sulfate. Tingling is not a common side effect or typical allergy sign, but monitoring for unusual reactions is advised.

      community Switching from finasteride to dutasteride.

      in Finasteride  76 upvotes 1 week ago
      The user has been taking finasteride for nearly 5 years and is now adding dutasteride to their regimen to maintain hair loss prevention. They seek advice on transitioning from finasteride to dutasteride.

      community Increased Hair Shedding After Starting Finasteride

      in Finasteride  75 upvotes 1 month ago
      The user started finasteride in January 2025 and experienced increased hair shedding by March 2025, despite initial improvements from PRP treatment. They are concerned but have read that this shedding might be a temporary phase of the finasteride treatment.

    Related Research

    1 / 1 results