The Effects of Finasteride on the Expression of Dazl, Tsga10, Sycp3, Prm2 Genes During Spermatogenesis in Testes of NMRI Mice

    August 2020 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    S Mohebali, N Hayati Roodbari, Reza Hajihosseini, Kazem Parivar
    TLDR Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.
    The study, conducted on male NMRI mice for 35 days, investigated the impact of Finasteride on the expression of four biomarkers of the spermatogenesis process: Dazl, Tsga10, Sycp3, and Prm2. The mice were divided into three groups, each receiving different doses of Finasteride (1, 5, and 20 mg/body weight). The results showed that at a dose of 20 mg/body weight, the expression levels of Dazl and Prm2 genes significantly decreased. At doses of 5 and 20 mg/body weight, the expression levels of Sycp3 and Tsga10 genes were significantly reduced. The study concluded that Finasteride, at a dose of 5 mg/body weight or higher, might have adverse effects on male spermatogenesis and fertility.
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