The Effects of Finasteride on the Expression of Dazl, Tsga10, Sycp3, Prm2 Genes During Spermatogenesis in Testes of NMRI Mice

    August 2020 in “ DOAJ (DOAJ: Directory of Open Access Journals) ”
    S Mohebali, N Hayati Roodbari, Reza Hajihosseini, Kazem Parivar
    TLDR Finasteride, at doses of 5mg or higher, may negatively affect male fertility by reducing the expression of certain genes involved in sperm production.
    The study, conducted on male NMRI mice for 35 days, investigated the impact of Finasteride on the expression of four biomarkers of the spermatogenesis process: Dazl, Tsga10, Sycp3, and Prm2. The mice were divided into three groups, each receiving different doses of Finasteride (1, 5, and 20 mg/body weight). The results showed that at a dose of 20 mg/body weight, the expression levels of Dazl and Prm2 genes significantly decreased. At doses of 5 and 20 mg/body weight, the expression levels of Sycp3 and Tsga10 genes were significantly reduced. The study concluded that Finasteride, at a dose of 5 mg/body weight or higher, might have adverse effects on male spermatogenesis and fertility.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Temporary alternative to finasteride?

      in Finasteride  99 upvotes 1 week ago
      A 23-year-old male plans to temporarily stop finasteride to donate plasma for financial reasons and seeks alternative hair loss treatments like minoxidil, ketoconazole, or RU58841 during this period. He is open to suggestions to prevent further hair loss until he can resume finasteride.

      community Sensitive liver, topical fin safe to try?

      in Finasteride  98 upvotes 1 week ago
      Topical finasteride is considered safer for the liver than oral finasteride due to less systemic absorption, but regular liver function tests are advised. The user is concerned about liver health due to a history of NAFLD and is exploring topical finasteride as a safer alternative.

      community 8 months Fin + Oral Minox - still losing some hairs, normal?

      in Finasteride  90 upvotes 2 weeks ago
      After 8 months of using oral Minoxidil 5mg and Finasteride 1mg, the user still experiences hair loss, particularly miniaturized hairs in the mid-scalp area, along with itching. They are concerned about losing around 40 hairs daily despite treatment.

    Related Research

    1 / 1 results