Finasteride

    March 2013 in “ Reactions Weekly ”
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    TLDR A man's fertility improved after he stopped taking finasteride but worsened again when he restarted the medication.
    A 40-year-old man experienced secondary infertility after using finasteride 1mg daily for 101 months (8.5 years) to treat hair loss from androgenetic alopecia. Laboratory tests revealed impaired semen parameters and a sperm DNA fragmentation index (SDFI) greater than 30%, indicating DNA damage. Upon discontinuing finasteride, his semen volume, count, and motility improved within 8 months, and his SDFI decreased. His wife became pregnant 11 months after he stopped taking the drug, and his semen parameters continued to improve 18 months after cessation. However, after the man restarted finasteride, follow-up tests at 3 months and 19 months showed a decline in semen volume, sperm count, and motility, although his SDFI was not affected. This case suggests that prolonged use of low-dose finasteride may cause reversible secondary infertility.
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      community Fresh off the press: Dutasteride may cause chronic infertility

      in Research/Science  643 upvotes 3 months ago
      Dutasteride may cause chronic infertility by reducing semen volume and motility, with concerns about irreversible prostate fibrosis. Users consider switching to finasteride or using treatments like minoxidil and microneedling, weighing hair preservation against fertility.

      community The meds work: my dad at 23 yo vs me at 35 yo

      in Finasteride/Dutasteride  1748 upvotes 2 weeks ago
      Finasteride and oral minoxidil effectively maintain a youthful appearance and full head of hair, despite genetic predispositions to balding. The discussion also considers the impact of DHT blockers on masculinity and aging, with lifestyle choices like sunscreen use and a vegetarian diet mentioned.

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